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Case Reports
. 2021 Apr 16:22:101095.
doi: 10.1016/j.ajoc.2021.101095. eCollection 2021 Jun.

Isolated deep orbital hemangioma treated successfully with oral propranolol in a 2-month-old infant: Case report with literature review

Denisa Zvizdic  1 , Deniz Bulja  2 , Amila Sidran  3 , Faruk Skenderi  4 , Zlatan Zvizdic  5 , Semir Vranic  6   7
Affiliations
Case Reports

Isolated deep orbital hemangioma treated successfully with oral propranolol in a 2-month-old infant: Case report with literature review

Denisa Zvizdic et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: Infantile hemangiomas (IH) are the most common benign vascular tumors of infancy. Ocular complications due to orbital IH include strabismal, deprivational, or anisometropic astigmatism, and visual loss secondary to amblyopia.

Observations: We report a case of a two-month-old female infant with a severe deep orbital IH. The diagnosis was established by clinical examination and magnetic resonance imaging (MRI). The patient was treated with oral propranolol for six months. Complete tumor regression was observed clinically and by MRI following the treatment. The patient showed no adverse effects or tumor recurrence at the 14-month follow-up.

Conclusions and importance: Despite its benign nature, periorbital IH requires a rapid diagnosis and prompt treatment to prevent vision loss, particularly in infants. Our case confirms that oral propranolol may be regarded as a safe drug for periorbital IH with an excellent outcome.

Keywords: Benign tumors; Hemangioma; Infants; Propranolol; Treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
A-B. A: A photograph of the patient at the age of two months showing left eye proptosis and periorbital swelling (red arrow) (before treatment). B: A complete disappearance of the deep orbital hemangioma following the treatment with propranolol. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2
Fig. 2
A-B. Transverse T2 WI scans of the orbits: A: Initial finding with a large left intraorbital, extra- and intraconal T2 hyperintense mass (red arrow) in the lateral aspect of the orbit with consequent proptosis; B: Post-treatment complete disappearance of the deep orbital hemangioma with entirely resolved left proptosis. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
See this image and copyright information in PMC

References

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