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Review
. 2021 Sep;31(3):472-494.
doi: 10.1007/s11065-021-09481-9. Epub 2021 May 12.

Corticostriatal Regulation of Language Functions

David A Copland  1   2 , Sonia Brownsett  3   4 , Kartik Iyer  5 , Anthony J Angwin  3
Affiliations
Review

Corticostriatal Regulation of Language Functions

David A Copland et al. Neuropsychol Rev. 2021 Sep.

Abstract

The role of corticostriatal circuits in language functions is unclear. In this review, we consider evidence from language learning, syntax, and controlled language production and comprehension tasks that implicate various corticostriatal circuits. Converging evidence from neuroimaging in healthy individuals, studies in populations with subcortical dysfunction, pharmacological studies, and brain stimulation suggests a domain-general regulatory role of corticostriatal systems in language operations. The role of corticostriatal systems in language operations identified in this review is likely to reflect a broader function of the striatum in responding to uncertainty and conflict which demands selection, sequencing, and cognitive control. We argue that this role is dynamic and varies depending on the degree and form of cognitive control required, which in turn will recruit particular corticostriatal circuits and components organised in a cognitive hierarchy.

Keywords: Language; Learning; Lexical-semantic; Striatum; Syntax.

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