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Comment
. 2021 Jul 1;23(7):1197-1199.
doi: 10.1093/neuonc/noab058.

Validation of the prognostic value of 9-gene ATE score for IDH wild-type glioblastoma

Zihao Wang  1   2 , Lu Gao  1   2 , Yaning Wang  1   2 , Mengqi Chang  1   2 , Hao Xing  1   2 , Yu Wang  1   2 , Bing Xing  1   2 , Wenbin Ma  1   2
Affiliations
Comment

Validation of the prognostic value of 9-gene ATE score for IDH wild-type glioblastoma

Zihao Wang et al. Neuro Oncol. .
No abstract available

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Figures

Fig. 1
Fig. 1
(A) Kaplan-Meier survival analysis for OS using the ATE score in the TCGA GBM cohort. (B) Forest plots showing hazard ratios with 95% confidence intervals and P values for clinical variables and ATE score. (C) Comparisons of the infiltration level of stromal (stromal score) and immune (immune score) cells, the ESTIMATE score, and tumor purity in high- and low-ATE score group by boxplots. (D) Comparisons of the abundances of 22 immune cells in high- and low-ATE score group by boxplots. (E) Comparisons of the TMB in high- and low-ATE score group by boxplots. (F) Comparisons of the abundances of blood-derived and microglial TAMs in high- and low-ATE score group by boxplots. (G) Comparisons of the expressions of six immune checkpoint molecules in high- and low-ATE score group by boxplots. (H) Boxplots showing the TIDE scores in high- and low-ATE score group. (I) Comparisons of the proportions of nonresponders and responders to immunotherapy in high- and low-ATE score group. (J) Boxplot showing the difference in the AUC values of TMZ estimated by pRRophetic algorithm based on CTRP database between high- and low-ATE score group. Lower AUC value indicated increased sensitivity to TMZ therapy. “ns” means P > .05, * means P < .05, ** means P < .01, *** means P < .001, and **** means P < .0001. Abbreviations: AUC, area under the dose-response curve; KPS, Karnofsky performance status; MGMT, O6-methylguanine DNA methyltransferase; OS, overall survival; TAM, tumor-associated macrophage; TIDE, Tumor Immune Dysfunction and Exclusion; TMB, tumor mutation burden; TMZ, temozolomide.
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