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. 2021 May 14;70(19):712-716.
doi: 10.15585/mmwr.mm7019e1.

Rapid Emergence and Epidemiologic Characteristics of the SARS-CoV-2 B.1.526 Variant - New York City, New York, January 1-April 5, 2021

Corinne N Thompson, Scott Hughes, Stephanie Ngai, Jennifer Baumgartner, Jade C Wang, Emily McGibbon, Katelynn Devinney, Elizabeth Luoma, Daniel Bertolino, Christina Hwang, Kelsey Kepler, Cybill Del Castillo, Melissa Hopkins, Henry Lee, Andrea K DeVito, Jennifer L Rakeman; PhD1; Anne D Fine

Rapid Emergence and Epidemiologic Characteristics of the SARS-CoV-2 B.1.526 Variant - New York City, New York, January 1-April 5, 2021

Corinne N Thompson et al. MMWR Morb Mortal Wkly Rep. .

Abstract

Recent studies have documented the emergence and rapid growth of B.1.526, a novel variant of interest (VOI) of SARS-CoV-2, the virus that causes COVID-19, in the New York City (NYC) area after its identification in NYC in November 2020 (1-3). Two predominant subclades within the B.1.526 lineage have been identified, one containing the E484K mutation in the receptor-binding domain (1,2), which attenuates in vitro neutralization by multiple SARS-CoV-2 antibodies and is present in variants of concern (VOCs) first identified in South Africa (B.1.351) (4) and Brazil (P.1).* The NYC Department of Health and Mental Hygiene (DOHMH) analyzed laboratory and epidemiologic data to characterize cases of B.1.526 infection, including illness severity, transmission to close contacts, rates of possible reinfection, and laboratory-diagnosed breakthrough infections among vaccinated persons. Preliminary data suggest that the B.1.526 variant does not lead to more severe disease and is not associated with increased risk for infection after vaccination (breakthrough infection) or reinfection. Because relatively few specimens were sequenced over the study period, the statistical power might have been insufficient to detect modest differences in rates of uncommon outcomes such as breakthrough infection or reinfection. Collection of timely viral genomic data for a larger proportion of citywide cases and rapid integration with population-based surveillance data would enable improved understanding of the impact of emerging SARS-CoV-2 variants and specific mutations to help guide public health intervention efforts.

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Conflict of interest statement

All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Cybill Del Castillo, Henry Lee, and Melissa Hopkins are employed by Opentrons Labworks/ReOpen Diagnostics DBA Pandemic Response Lab, which offers real-time polymerase chain reaction testing and biosurveillance sequencing for COVID-19. No other potential conflicts of interest were disclosed.

Figures

FIGURE
FIGURE
Number of specimens undergoing whole genome sequencing (A) and percentage of specimens with B1.526 variant with or without E484K mutation, B.1.1.7 variant, and other variants of concern or interest (B), by week of specimen collection — New York City, New York, January 1–April 5, 2021 Abbreviations: VOC = variant of concern; VOI = variant of interest. * Whole genome sequencing of specimens (collection date during January 1–April 5, 2021) from New York City residents was performed at the Public Health Laboratory or the Pandemic Response Laboratory.
See this image and copyright information in PMC

References

    1. Lasek-Nesselquist E, Lapierre P, Schneider E, George KS, Pata J. The localized rise of a B.1.526 SARS-CoV-2 variant containing an E484K mutation in New York State. medRxiv [Preprint posted online March 1, 2021]. 10.1101/2021.02.26.21251868 - DOI
    1. West AP, Barnes CO, Yang Z, Bjorkman PJ. SARS-CoV-2 lineage B.1.526 emerging in the New York region detected by software utility created to query the spike mutation landscape. bioRxiv [Preprint posted online February 23, 2021]. 10.1101/2021.02.14.431043 - DOI
    1. Annavajhala MK, Mohri H, Zucker JE, et al. A novel SARS-CoV-2 variant of concern, B.1.526, identified in New York. medRxiv [Preprint posted online February 25, 2021]. 10.1101/2021.02.23.21252259 - DOI
    1. Tegally H, Wilkinson E, Giovanetti M, et al. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature 2021;592:438–43. 10.1038/s41586-021-03402-9 - DOI - PubMed
    1. Grubaugh ND, Gangavarapu K, Quick J, et al. An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar. Genome Biol 2019;20:8. 10.1186/s13059-018-1618-7 - DOI - PMC - PubMed