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Case Reports
. 2020 Jul;11(7):211-214.
doi: 10.14740/jmc3520. Epub 2020 Jun 29.

Macrophage Activation in COVID-19 Patients in Intensive Care Unit

Guylaine Labro  1 , Louise Marie Jandeaux  1 , Andreea Rusu  1 , Edouard Virot  1 , Valentin Pointurier  1 , Luis Pinto  1 , Cyrille Mathien  1 , Agathe Debliquis  2 , Ines Harzallah  2 , Joy Mootien  1 , Bernard Drenou  2 , Khaldoun Kuteifan  1
Affiliations
Case Reports

Macrophage Activation in COVID-19 Patients in Intensive Care Unit

Guylaine Labro et al. J Med Cases. 2020 Jul.

Abstract

We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountered during a hemophagocytic lymphohistiocytosis. These observations might evoke a macrophage activation mechanism different from the one encountered in the hemophagocytic lymphohistiocytosis (HLH).

Keywords: COVID-19; Hemophagocytic lymphohistiocytosis; Macrophage activation.

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Conflict of interest statement

None to declare.

Figures

Figure 1
Figure 1
Bone marrow sample (magnification, × 50). May-Grunwald-Giemsa staining of bone marrow aspirate shows two histiocytes with engulfed nucleated cells (one neutrophil (green arrow) and one erythroblast (red arrow)).
See this image and copyright information in PMC

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