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Review
. 2020 Aug;10(4):107-112.
doi: 10.14740/jnr603. Epub 2020 Jun 23.

The Neurologic Manifestations of Coronavirus Disease 2019

Amjad Elmashala  1 , Saurav Chopra  2 , Aayushi Garg  1
Affiliations
Review

The Neurologic Manifestations of Coronavirus Disease 2019

Amjad Elmashala et al. J Neurol Res. 2020 Aug.

Abstract

The coronavirus disease 2019 (COVID-19) is an ongoing global pandemic that has so far affected 216 countries and more than 5 million individuals worldwide. The infection is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While pulmonary manifestations are the most common, neurological features are increasingly being recognized as common manifestations of the COVID-19, especially in the cases of severe infection. These include acute cerebrovascular disease, encephalitis, and Guillain-Barre syndrome (GBS). Here, we review the neuropathogenesis of SARS-CoV-2 and the central and peripheral nervous system manifestations of COVID-19.

Keywords: Anosmia; COVID-19; Coronavirus; Encephalitis; GBS; Myelitis; Neurologic; Stroke.

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Conflict of interest statement

None to declare.

References

    1. World Health Organization. Coronavirus disease (COVID-19) pandemic. [cited May 18, 2020]; Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
    1. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci. 2020;11(7):995–998. doi: 10.1021/acschemneuro.0c00122. - DOI - PubMed
    1. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;109:102433. doi: 10.1016/j.jaut.2020.102433. - DOI - PMC - PubMed
    1. Jin H, Hong C, Chen S, Zhou Y, Wang Y, Mao L, Li Y. et al. Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists. Stroke Vasc Neurol. 2020 doi: 10.1136/svn-2020-000382. - DOI - PMC - PubMed
    1. Desforges M, Le Coupanec A, Stodola JK, Meessen-Pinard M, Talbot PJ. Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis. Virus Res. 2014;194:145–158. doi: 10.1016/j.virusres.2014.09.011. - DOI - PMC - PubMed

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