Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 May 12;29(5):675-677.
doi: 10.1016/j.chom.2021.04.012.

CRISPR transposons on the move

Ioannis Mougiakos  1 , Chase L Beisel  2
Affiliations
Free article
Comment

CRISPR transposons on the move

Ioannis Mougiakos et al. Cell Host Microbe. .
Free article

Abstract

CRISPR transposons (CASTs) represent unique mobile genetic elements that co-opted CRISPR-Cas immune systems for RNA-guided DNA transposition. However, CAST-encoded CRISPR arrays rarely match the CAST's chromosomal location. A recent publication in Cell helps resolve this paradox by revealing CRISPR-array-independent mechanisms of chromosomal homing unique to different CAST types.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests C.L.B. is a co-founder of Locus Biosciences and a member of its scientific advisory board, and a member of the scientific advisory board of Benson Hill.

Comment on

  • Dual modes of CRISPR-associated transposon homing.
    Saito M, Ladha A, Strecker J, Faure G, Neumann E, Altae-Tran H, Macrae RK, Zhang F. Saito M, et al. Cell. 2021 Apr 29;184(9):2441-2453.e18. doi: 10.1016/j.cell.2021.03.006. Epub 2021 Mar 25. Cell. 2021. PMID: 33770501 Free PMC article.

MeSH terms

Substances

LinkOut - more resources