Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 May 12;29(5):740-741.
doi: 10.1016/j.chom.2021.04.013.

Debaryomyces, the Achilles heel of wound repair

Carol A Kumamoto  1 , Jesus A Romo  2
Affiliations
Comment

Debaryomyces, the Achilles heel of wound repair

Carol A Kumamoto et al. Cell Host Microbe. .

Abstract

In a recent Science paper, Jain et al. (2021) discover that a fungus contributes to delayed wound healing in mice and is enriched in inflamed tissue from Crohn's disease patients. This culprit is not a well-known pathogen, but cheese yeast Debaryomyces hansenii, highlighting the importance of further studying fungi-host interactions.

PubMed Disclaimer

Comment on

References

    1. Cao Y, Wang L, Ke S, Villafuerte Galvez JA, Pollock NR, Barret C, Sprague R, Daugherty K, Xu H, Lin Q, et al. (2021). Fecal Mycobiota Combined With Host Immune Factors Distinguish Clostridioides difficile Infection From Asymptomatic Carriage. Gastroenterology. - PMC - PubMed
    1. Hoarau G, Mukherjee PK, Gower-Rousseau C, Hager C, Chandra J, Retuerto MA, Neut C, Vermeire S, Clemente J, Colombel JF, et al. (2016). Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease. mBio 7. - PMC - PubMed
    1. Jain U, Ver Heul AM, Xiong S, Gregory MH, Demers EG, Kern JT, Lai CW, Muegge BD, Barisas DAG, Leal-Ekman JS, et al. (2021). Debaryomyces is enriched in Crohn’s disease intestinal tissue and impairs healing in mice. Science 371, 1154–1159. - PMC - PubMed
    1. Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, Lee D, Bittinger K, Bailey A, Friedman ES, Hoffmann C, et al. (2015). Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease. Cell Host Microbe 18, 489–500. - PMC - PubMed
    1. Priest SJ, and Lorenz MC (2015). Characterization of Virulence-Related Phenotypes in Candida Species of the CUG Clade. Eukaryot Cell 14, 931–940. - PMC - PubMed