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Observational Study
. 2021 May 13;19(1):69.
doi: 10.1186/s12958-021-00757-6.

Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

Raoul Orvieto  1   2   3 , Meirav Noach-Hirsh  4   5 , Aliza Segev-Zahav  4   5 , Jigal Haas  4   5 , Ravit Nahum  4   5 , Adva Aizer  4   5
Affiliations
Observational Study

Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

Raoul Orvieto et al. Reprod Biol Endocrinol. .

Abstract

Objective: No information exists in the literature regarding the effect of mRNA SARS-CoV-2 vaccine on subsequent IVF cycle attempt. We therefore aim to assess the influence of mRNA SARS-CoV-2 vaccine on IVF treatments.

Design: An observational study.

Setting: A tertiary, university-affiliated medical center.

Patients and methods: All couples undergoing consecutive ovarian stimulation cycles for IVF before and after receiving mRNA SARS-CoV-2 vaccine, and reached the ovum pick-up (OPU) stage. The stimulation characteristics and embryological variables of couples undergoing IVF treatments after receiving mRNA SARS-CoV-2 vaccine were assessed and compared to their IVF cycles prior to vaccination.

Main outcome measures: Stimulation characteristics and embryological variables.

Results: Thirty-six couples resumed IVF treatment 7-85 days after receiving mRNA SARS-CoV-2 vaccine. No in-between cycles differences were observed in ovarian stimulation and embryological variables before and after receiving mRNA SARS-CoV-2 vaccination.

Conclusions: mRNA SARS-CoV-2 vaccine did not affect patients' performance or ovarian reserve in their immediate subsequent IVF cycle. Future larger studies with longer follow-up will be needed to validate our observations.

Keywords: COVID-19; IVF; Ovarian stimulation; embryo quality; vaccination.

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Conflict of interest statement

Authors have nothing to declare.

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