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Observational Study
. 2021 May 13;19(1):69.
doi: 10.1186/s12958-021-00757-6.

Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

Raoul Orvieto  1   2   3 , Meirav Noach-Hirsh  4   5 , Aliza Segev-Zahav  4   5 , Jigal Haas  4   5 , Ravit Nahum  4   5 , Adva Aizer  4   5
Affiliations
Observational Study

Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

Raoul Orvieto et al. Reprod Biol Endocrinol. .

Abstract

Objective: No information exists in the literature regarding the effect of mRNA SARS-CoV-2 vaccine on subsequent IVF cycle attempt. We therefore aim to assess the influence of mRNA SARS-CoV-2 vaccine on IVF treatments.

Design: An observational study.

Setting: A tertiary, university-affiliated medical center.

Patients and methods: All couples undergoing consecutive ovarian stimulation cycles for IVF before and after receiving mRNA SARS-CoV-2 vaccine, and reached the ovum pick-up (OPU) stage. The stimulation characteristics and embryological variables of couples undergoing IVF treatments after receiving mRNA SARS-CoV-2 vaccine were assessed and compared to their IVF cycles prior to vaccination.

Main outcome measures: Stimulation characteristics and embryological variables.

Results: Thirty-six couples resumed IVF treatment 7-85 days after receiving mRNA SARS-CoV-2 vaccine. No in-between cycles differences were observed in ovarian stimulation and embryological variables before and after receiving mRNA SARS-CoV-2 vaccination.

Conclusions: mRNA SARS-CoV-2 vaccine did not affect patients' performance or ovarian reserve in their immediate subsequent IVF cycle. Future larger studies with longer follow-up will be needed to validate our observations.

Keywords: COVID-19; IVF; Ovarian stimulation; embryo quality; vaccination.

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Conflict of interest statement

Authors have nothing to declare.

References

    1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
    1. ASRM patient management and clinical recommendations during the CORONAVIRUS (COVID-19) pandemic Update No. 10 (November 17,2020). https://www.asrm.org/globalassets/asrm/asrm-content/news-andpublications....
    1. Barragan M, Guillén JJ, Martin-Palomino N, Rodriguez A, Vassena R. Undetectable viral RNA in oocytes from SARS-CoV-2 positive women. Hum Reprod Sep. 2020;30:deaa284. doi: 10.1093/humrep/deaa284. - DOI - PMC - PubMed
    1. Ruan Y, Hu B, Liu Z, Liu K, Jiang H, Li H, Li R, Luan Y, Liu X, Yu G, Xu S, Yuan X, Wang S, Yang W, Ye Z, Liu J, Wang T. (2020) No Detection of SARS-CoV-2 from Urine, Expressed Prostatic Secretions and Semen in 74 Recovered COVID-19 Male Patients: A Perspective and Urogenital Evaluation. Andrology. Nov 4. 10.1111/andr.12939. Epub ahead of print. PMID: 33150723. - PubMed
    1. Gleicher N, Barad D. Unexplained infertility: Does it really exist? Hum Reprod. 2006;21:1951–530. doi: 10.1093/humrep/del135. - DOI - PubMed

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