Induction of lymphokines by tilorone
- PMID: 339871
Item in Clipboard
Induction of lymphokines by tilorone
Arch Immunol Ther Exp (Warsz).
1977.
Abstract
Serum obtained 16 hr after p.o. application of tilorone [2, 7-bis/2-diethylaminoethoxy/-fluoren-9-one dihydrochloride] to ABD2F1 mice demonstrated both interferon and migration inhibitory (MIF) activity. Kinetic studies showed a close correspondence between interferon and MIF serum levels. The physiochemical characteristics of tilorone-induced MIF (heat and pH lability, molecular size) are compared with those of MIF generated in in vitro lymphocyte cultures. The findings are discussed in relation to production of lymphocytogenic lymphokines.
Similar articles
-
Reticuloendothelial cells as the site of production of MIF induced by tilorone hydrochloride.J Reticuloendothel Soc. 1979 Mar;25(3):293-7. J Reticuloendothel Soc. 1979. PMID: 220421 No abstract available.
-
Immune interferon. II. Different cellular site for the production of murine macrophage migration inhibitory factor and interferon.Eur J Immunol. 1978 Aug;8(8):582-9. doi: 10.1002/eji.1830080809. Eur J Immunol. 1978. PMID: 359337
-
Induction of cytokines by tilorone hydrochloride.Agents Actions. 1978 Oct;8(5):515-22. doi: 10.1007/BF02111439. Agents Actions. 1978. PMID: 717185
-
Inflammatory, non-antibody lymphocytic mediators (lymphokines).Allerg Immunol (Leipz). 1980;26(4):293-309. Allerg Immunol (Leipz). 1980. PMID: 6163346 Review.
-
Tilorone and related bis-basic substituted polycyclic aromatic and heteroaromatic compounds.Prog Med Chem. 1981;18:135-90. doi: 10.1016/s0079-6468(08)70319-9. Prog Med Chem. 1981. PMID: 7045982 Review. No abstract available.
MeSH terms
Substances
LinkOut - more resources
Miscellaneous