[Prognostic factors in the chemoradiation treatment of III-stage lymphogranulomatosis]

Abstract

The results of therapy of 152 patients with stage III Hodgkin's disease (106--IIIA, 46--IIIB) were studied. The administration of 2-4 cycles of polychemotherapy (MOPP scheme including embichin, vincristine, procarbazine and prednisolone) followed by large field irradiation after a radical program in 2-4 weeks was envisaged in the therapeutic plan. Cox's multifactor regression analysis made it possible to determine the values of some indices for the outcome of disease. The main prognostic factors in chemo- and radiotherapy were a histological type and mediastinal lymph node involvement. The fact of the involvement of the mediastinal lymph nodes in a tumor process rather than a degree of their enlargement played a decisive role. Such prognostic factors as male sex and the age over 40 were regarded as unfavorable, however their role was not as important as that of a histological type and mediastinal lymph node involvement. The above program of chemo- and radiotherapy made it possible to reduce the effect of general symptoms and signs of "biological activity" of a process.