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Case Reports
. 2021 May 12;92(2):e2021106.
doi: 10.23750/abm.v92i2.9482.

Osteoclast: like giant cell undiferrentiated pancreatic tumor diagnosed by means of EUS guided FNA

Alexandra Kalogeraki  1 , Ioannis Mouzas  2 , Ioannis E Koutroubakis  3 , Eleni Moustou  4 , Eleni Lappa  5 , Dimitrios Tamiolakis  6 , Aggeliki Machaira  7 , Eleni Orfanoudaki  8 , Evangelos Kalaitzakis  9
Affiliations
Case Reports

Osteoclast: like giant cell undiferrentiated pancreatic tumor diagnosed by means of EUS guided FNA

Alexandra Kalogeraki et al. Acta Biomed. .

Abstract

Objective: Osteoclast-like giant cell tumours are rare abdominal malignant neoplasms mainly arising in the pancreas. Because of their rarity, clinical and cytopathology reports are very limited, and sonographic features have not been clearly specified ; these tumors are easily misdiagnosed by ultrasound as mucinous cystic tumors (MCTs) or solid pseudopapillary neoplasms (SPNs).

Case study: We report a case of osteoclast like giant cell tumor arising in the pancreas of an 80 year old female patient offered by EUS-FNA cytology on direct and cell block slides. A biphasic pattern composed by a malignant mononuclear cell component and a giant cell component were hallmarks to the diagnosis.

Conclusion: Our case highlights the performance of EUS-FNA in the diagnostic approach of abdominal tumours and the significance of cell block method in the interpretation of osteoclast-like giant cell pancreatic tumour.

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Figures

Figure 1.
Figure 1.
A Endoscopic ultrasound image of a hypoechoic lesion with irregular margins in the head of the pancreas. B Endoscopic ultrasound guided FNA from the lesion.
Figure 2.
Figure 2.
Osteoclast like giant cell pancreatic tumor. Cell block preparation. Hematoxylene-Eosin stain X 200.
Figure 3.
Figure 3.
Osteoclast like giant cell pancreatic tumor. Cell block preparation. CEA immunostain X 400.
Figure 4.
Figure 4.
Osteoclast like giant cell pancreatic tumor. Cell block preparation. CD68 immunostain X 400.
See this image and copyright information in PMC

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References

    1. Buickoa JL, Lopez AM, Lopez-Viego MA. Surgical resection of a rare undifferentiated pancreatic carcinoma with osteoclast-like giant cells: a case review. J Med Cases. 2013;4(3):156–158.
    1. Maksymov V, Khalifa MA, Bussey A, Carter B, Hogan M. Undifferentiated (anaplastic) carcinoma of the pancreas with osteoclast-like giant cells showing various degree of pancreas duct involvement. A case report and literature review. JOP. 2011;12(2):170–176. - PubMed
    1. Rosai J. Carcinoma of pancreas simulating giant cell tumor of bone: electron-microscopic evidence of its acinar cell origin. Cancer. 1968;22(2):333–344. - PubMed
    1. Nigam N, Rastogi A, Bhatia V, Sureka B, et al. EUS-guided FNA in Diagnosing Pancreatic Lesions: Strength and Cytological Spectrum. J Cytol. 2019 Oct-Dec;36(4):189–195. - PMC - PubMed
    1. Kloppel G, Hruban RH, Longnecker DS. Ductal adenocarcinoma of pancreas. In: Hamilton SR, Aaltonen LA, editors. WHO classification of tumors. Pathology and Genetics of tumors of the digestive system. Lyon: IARC Press; 2000.

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