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Review
. 2021 Apr;48(4):3733-3745.
doi: 10.1007/s11033-021-06367-0. Epub 2021 May 14.

Pharmacological and therapeutic applications of Sinapic acid-an updated review

Anandakumar Pandi  1 , Vanitha Manickam Kalappan  2
Affiliations
Review

Pharmacological and therapeutic applications of Sinapic acid-an updated review

Anandakumar Pandi et al. Mol Biol Rep. 2021 Apr.

Abstract

Phenolic compounds, present in plants, are considered to be indispensable parts of human dietary sources. Sinapic acid, is a natural herbal compound containing phenolic acid. It is found in oranges, grapefruits, and cranberries and in herbs like canola, mustard seed and rapeseed. Sinapic acid is chemically studied as a cinnamic acid derivative that contains 3, 5-dimethoxyl and 4-hydroxyl substitutions in the phenyl group of cinnamic acid. Sinapic acid has been pharmacologically evaluated for its potent antioxidant, anti-inflammatory, anti-cancer, hepatoprotective, cardioprotective, renoprotective, neuroprotective, anti-diabetic, anxiolytic and anti-bacterial activities. In this review we have summarized the potential pharmacological and therapeutic effects of Sinapic acid in various models.

Keywords: Anti-cancer; Anti-inflammatory; Antioxidant; Cardioprotective; Neuroprotective; Sinapic acid.

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References

    1. Robbins RJ (2003) Phenolic acids in foods: an overview of analytical methodology. J Agri Food Chem. 51:2866–2887
    1. Soobrattee MA, Nergheen VA, Luximonramma A, Aruoma OI, Bahorun T (2005) Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat. Res. 579:200–213 - PubMed
    1. Ekor M (2014) The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 4:177 - PubMed - PMC
    1. Chen C (2016) Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress-Induced Diseases and Aging. Oxid Med Cell Longev 2016:3571614 - PubMed
    1. Menezes JC, Kamat SP, Cavaleiro JA, Gaspar A, Garrido J, Borges F (2011) Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates. Eur J Med Chem 46(2):773–777 - PubMed

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