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. 2021 May 13;184(10):2525-2531.
doi: 10.1016/j.cell.2021.03.041.

Ancestry matters: Building inclusivity into preclinical study design

Sophie Zaaijer  1 , Amanda Capes-Davis  2
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Free article

Ancestry matters: Building inclusivity into preclinical study design

Sophie Zaaijer et al. Cell. .
Free article

Abstract

Human cell lines (CLs) are key assets for biomedicine but lack ancestral diversity. Here, we explore why genetic diversity among cell-based models is essential for making preclinical research more equitable and widely translatable. We lay out practical actions that can be taken to improve inclusivity in study design.

Keywords: GWAS; HeLa; ancestry; cell lines; diversity; drug discovery; pharmacogenomics; precision medicine.

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Conflict of interest statement

Declaration of interests S.Z. is the founder of FIND Genomics, a company that aims to improve reproducible cell-based science. FIND Genomics is the creator of FIND Cell, a cell-line tracking software (https://findgen.bio/). A.C.D. receives payments as a consultant for FIND Genomics.

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