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Comment
. 2021 May 13;184(10):2534-2536.
doi: 10.1016/j.cell.2021.04.030.

Tracking self-performance in the prefrontal cortex: It's layered

Affiliations
Comment

Tracking self-performance in the prefrontal cortex: It's layered

Shannon S Schiereck et al. Cell. .

Abstract

In this issue of Cell, Spellman and colleagues record and manipulate the activity of neurons in the medial prefrontal cortex of mice performing a task in which they must pay attention to different stimuli. They show that this brain region is important for monitoring the animals' performance, and neurons that appear to contribute to behavior reside in deep cortical layers.

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Figures

Figure 1.
Figure 1.. How does mPFC contribute to attentional set-shifting?
(A) Simplified timeline of the attentional set-shifting task used by Spellman et al. (2021). mPFC activity was necessary during the time of outcome feedback rather than during the trial, suggesting mPFC is important for performance monitoring. (B) Response heterogeneity of mPFC cells in the present study was related to the layer in which the cell resided rather than the cell’s projection target (efferent connectivity).

Comment on

  • Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.
    Washington NL, Gangavarapu K, Zeller M, Bolze A, Cirulli ET, Schiabor Barrett KM, Larsen BB, Anderson C, White S, Cassens T, Jacobs S, Levan G, Nguyen J, Ramirez JM 3rd, Rivera-Garcia C, Sandoval E, Wang X, Wong D, Spencer E, Robles-Sikisaka R, Kurzban E, Hughes LD, Deng X, Wang C, Servellita V, Valentine H, De Hoff P, Seaver P, Sathe S, Gietzen K, Sickler B, Antico J, Hoon K, Liu J, Harding A, Bakhtar O, Basler T, Austin B, MacCannell D, Isaksson M, Febbo PG, Becker D, Laurent M, McDonald E, Yeo GW, Knight R, Laurent LC, de Feo E, Worobey M, Chiu CY, Suchard MA, Lu JT, Lee W, Andersen KG. Washington NL, et al. Cell. 2021 May 13;184(10):2587-2594.e7. doi: 10.1016/j.cell.2021.03.052. Epub 2021 Mar 30. Cell. 2021. PMID: 33861950 Free PMC article.
  • Early introductions and transmission of SARS-CoV-2 variant B.1.1.7 in the United States.
    Alpert T, Brito AF, Lasek-Nesselquist E, Rothman J, Valesano AL, MacKay MJ, Petrone ME, Breban MI, Watkins AE, Vogels CBF, Kalinich CC, Dellicour S, Russell A, Kelly JP, Shudt M, Plitnick J, Schneider E, Fitzsimmons WJ, Khullar G, Metti J, Dudley JT, Nash M, Beaubier N, Wang J, Liu C, Hui P, Muyombwe A, Downing R, Razeq J, Bart SM, Grills A, Morrison SM, Murphy S, Neal C, Laszlo E, Rennert H, Cushing M, Westblade L, Velu P, Craney A, Cong L, Peaper DR, Landry ML, Cook PW, Fauver JR, Mason CE, Lauring AS, St George K, MacCannell DR, Grubaugh ND. Alpert T, et al. Cell. 2021 May 13;184(10):2595-2604.e13. doi: 10.1016/j.cell.2021.03.061. Epub 2021 Apr 3. Cell. 2021. PMID: 33891875 Free PMC article.

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