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Comment
. 2021 Aug;83(2):237-279.
doi: 10.1016/j.jinf.2021.04.037. Epub 2021 May 11.

Impact of COVID-19 vaccination program on seroprevalence in blood donors in England, 2021

Heather J Whitaker  1 , Suzanne Elgohari  2 , Cathy Rowe  3 , Ashley David Otter  3 , Tim Brooks  3 , Ezra Linley  4 , Iain Hayden  2 , Sonia Ribeiro  2 , Jacqueline Hewson  3 , Anissa Lakhani  2 , Eleanor Clarke  2 , Camille Tsang  2 , Colin Nj Campbell  2 , Mary Ramsay  2 , Kevin Brown  2 , Gayatri Amirthalingam  2
Affiliations
Comment

Impact of COVID-19 vaccination program on seroprevalence in blood donors in England, 2021

Heather J Whitaker et al. J Infect. 2021 Aug.

Abstract

The COVID-19 vaccination programme commenced in England on 8th December 2020 primarily based on age; by 7th March 2021 approximately 93% of the English population aged 70+ years had received at least 1 dose of either the Pfizer BioNTech or AstraZeneca vaccines. Using a nucleoprotein assay that detects antibodies following natural infection only and a spike assay that detects infection and vaccine-induced responses, we aim to describe the impact of vaccination on SARS-CoV-2 antibody prevalence in English blood donors.

Keywords: Antibodies; Blood Donors; COVID-19; COVID-19 Serological Testing; COVID-19 vaccines; SARS-CoV-2; Surveys.

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Conflict of interest statement

Declaration of Competing Interest EL reports the Public Health England Vaccine Evaluation Unit performs contract research on behalf of GSK, Sanofi and Pfizer which is outside the submitted work. HW, SE, IH, SR, KB, GA, EC, AL, CT, CC, IH, SR, JH, CR, AO, TB, MR report no conflicts of interest.

Figures

Fig. 1
Fig. 1
SARS-CoV-2 antibody seropositivity based on the Roche S assay (S+, grey solid lines), the Roche N assay (N+, red dotted lines) in English blood donors by age group, weighted by NHS region and sex, rolling four weekly average from the 4 week period 25/11/2020 - 20/12/2020 to the 4 week period 22/02/2021 – 21/03/2021. Also shown is the percentage Roche S seropositive, Roche N seronegative (S+N-, blue dashed lines).
Fig. 2
Fig. 2
Cumulative dose 1 COVID-19 vaccine uptake by age group (age on 31/03/2021). Roche S positive, N negative is plotted for the 70–84 and 60–69 age groups to demonstrate the lag in antibody response. Age 70+ uptake is weighted by the 70–84 donor age distribution.
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