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Multicenter Study
. 2021 Jul:203:93-100.
doi: 10.1016/j.thromres.2021.05.001. Epub 2021 May 8.

Incidence and clinical profile of venous thromboembolism in hospitalized COVID-19 patients from Madrid region

Karmele Arribalzaga  1 , Inés Martínez-Alfonzo  2 , Carola Díaz-Aizpún  2 , Isabel Gutiérrez-Jomarrón  3 , Mario Rodríguez  4 , Nerea Castro Quismondo  4 , Elia Pérez-Fernández  5 , Diego Velasco-Rodríguez  6 , Elvira Gómez  7 , Begoña Fernández  8 , Alba Vilches  9 , Sara Martín-Herrero  10 , Lucía Castilla  3 , María Jesús Blanco  11 , María Del Mar Gutiérrez  11 , Isabel Rivas  11 , Cristina Pascual  12 , Belén Rosado  13 , Elena Sola  13 , Rosa Vidal-Laso  10 , Susana Asenjo  14 , María Asunción Mora Casado  14 , Laurentino Benito-Parra  15 , Itziar Carmona  16 , Karen Marín  17 , Natalia Acedo  18 , Natalia García-León  19 , Alexis Marcheco  20 , Carolina Guillén  21 , Cristina Fernández  22 , Ramón Rodríguez  23 , Laura Pardo  10 , Pablo Silva  12 , Laura Montero  8 , Mar Meijón  24 , Pilar Massó  24 , Pilar Llamas-Sillero  25 ; Asociación Madrileña de Hematología y Hemoterapia (AMHH)
Affiliations
Multicenter Study

Incidence and clinical profile of venous thromboembolism in hospitalized COVID-19 patients from Madrid region

Karmele Arribalzaga et al. Thromb Res. 2021 Jul.

Abstract

Background: COVID-19 related in-hospital venous thromboembolism (VTE) incidence is high but data reported vary significantly. Some studies show that up to half of the events are diagnosed early after admission.

Objectives: To study symptomatic VTE incidence in acute COVID-19 hospitalized patients and to describe timing of VTE diagnosis.

Methods: Multicenter cohort of 5966 patients hospitalized with acute COVID-19. Multicenter Registry of 844 hospitalized patients with acute COVID-19 and associated acute VTE.

Results: By the time of cohort data collection, 68 patients (1.14%) were still hospitalized, 19.8% had died, and 5.4% required ICU. During a median follow-up of 6 days (IQR, 4-12), 183 patients (3.07%; 95% CI, 2.64-3.55) presented a symptomatic VTE event. The cumulative incidences of VTE at 7, 14 and 21 days in wards [2.3% (95% CI, 1.9-2.7), 3.6% (95% CI, 3.0-4.3), and 4.3% (95% CI, 3.5-5.1)] were similar to the ones reported in ICU [2.2% (95% CI, 1.0-4.4), 2.9% (95% CI, 1.5-5.3), and 4.1% (95% CI, 2.2-6.8)], but at 30 and 60 days were higher in ICU [6.9% (95% CI, 4.2-10.5), and 12.8% (95% CI, 8.1-18.5)] than in wards. Eighty-eight VTE events (48%) were diagnosed early, within 48 h of admission. VTE was not associated with death (HR, 0.79; 95% CI, 0.55-1.12).

Conclusions: Incidence of symptomatic VTE in our COVID-19 cohort is consistent with that of other real-life studies recently published. Early VTE events are, along with COVID-19, the reason for admission rather than an in-hospital complication.

Keywords: COVID19; Incidence; Multicenter study; Pulmonary embolism; Thromboprophylaxis; Venous thromboembolism.

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Conflict of interest statement

The authors declare that they have no known competing financialinterestsor personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Cumulative incidence of symptomatic VTE in ward and ICU patients.
Fig. 2
Fig. 2
Hospital survival by VTE.
See this image and copyright information in PMC

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