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Comment
. 2021 May 14;6(59):eabi5830.
doi: 10.1126/sciimmunol.abi5830.

CMV, MHC-E, and the quest for an unconventional AIDS vaccine

Bruce D Walker  1
Affiliations
Comment

CMV, MHC-E, and the quest for an unconventional AIDS vaccine

Bruce D Walker. Sci Immunol. .

Abstract

In the evolutionary battle between virus and host, a genetic alteration in cytomegalovirus caused by an inversion-deletion event during tissue culture passage opens an unconventional path toward an HIV vaccine (see the related Research Articles by Malouli et al., Yang et al., and Verweij et al.).

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  • HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities.
    Yang H, Rei M, Brackenridge S, Brenna E, Sun H, Abdulhaqq S, Liu MKP, Ma W, Kurupati P, Xu X, Cerundolo V, Jenkins E, Davis SJ, Sacha JB, Früh K, Picker LJ, Borrow P, Gillespie GM, McMichael AJ. Yang H, et al. Sci Immunol. 2021 Mar 25;6(57):eabg1703. doi: 10.1126/sciimmunol.abg1703. Sci Immunol. 2021. PMID: 33766848 Free PMC article.
  • Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy.
    Malouli D, Hansen SG, Hancock MH, Hughes CM, Ford JC, Gilbride RM, Ventura AB, Morrow D, Randall KT, Taher H, Uebelhoer LS, McArdle MR, Papen CR, Espinosa Trethewy R, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Greene JM, Axthelm MK, Shao J, Edlefsen PT, Grey F, Nelson JA, Lifson JD, Streblow D, Sacha JB, Früh K, Picker LJ. Malouli D, et al. Sci Immunol. 2021 Mar 25;6(57):eabg5413. doi: 10.1126/sciimmunol.abg5413. Sci Immunol. 2021. PMID: 33766849 Free PMC article.