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Case Reports
. 2021 Jul 1;40(7):e274-e276.
doi: 10.1097/INF.0000000000003146.

First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barré Syndrome

Naiana Mota Araújo  1 , Lis Campos Ferreira  2   3   4 , Débora Paraíso Dantas  3 , Denison Santos Silva  3 , Cliomar Alves Dos Santos  5 , Rosana Cipolotti  4 , Paulo Ricardo Martins-Filho  4   6
Affiliations
Case Reports

First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barré Syndrome

Naiana Mota Araújo et al. Pediatr Infect Dis J. .

Abstract

Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurologic complications are still poorly understood. Cases of Guillain-Barré Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric case of GBS with detection of SARS-CoV-2 in the cerebrospinal fluid (CFS). This unique case of COVID-19-associated GBS with detection of SARS-CoV-2 RNA in the CSF indicates direct viral involvement inducing peripheral nerve inflammation.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

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