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Case Reports
. 2021 Jul 1;40(7):e274-e276.
doi: 10.1097/INF.0000000000003146.

First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barré Syndrome

Naiana Mota Araújo  1 , Lis Campos Ferreira  2   3   4 , Débora Paraíso Dantas  3 , Denison Santos Silva  3 , Cliomar Alves Dos Santos  5 , Rosana Cipolotti  4 , Paulo Ricardo Martins-Filho  4   6
Affiliations
Case Reports

First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barré Syndrome

Naiana Mota Araújo et al. Pediatr Infect Dis J. .

Abstract

Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurologic complications are still poorly understood. Cases of Guillain-Barré Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric case of GBS with detection of SARS-CoV-2 in the cerebrospinal fluid (CFS). This unique case of COVID-19-associated GBS with detection of SARS-CoV-2 RNA in the CSF indicates direct viral involvement inducing peripheral nerve inflammation.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

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References

    1. Ellul MA, Benjamin L, Singh B, et al. Neurological associations of COVID-19. Lancet Neurol. 2020; 19:767–783
    1. Chen R, Wang K, Yu J, et al. The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in the human and mouse brains. Front Neurol. 2020; 11:573095
    1. Uncini A, Vallat JM, Jacobs BC.Guillain-Barré syndrome in SARS-CoV-2 infection: an instant systematic review of the first six months of pandemic. J Neurol Neurosurg Psychiatry. 2020; 91:1105–1110
    1. Baig AM, Sanders EC.Potential neuroinvasive pathways of SARS-CoV-2: deciphering the spectrum of neurological deficit seen in coronavirus disease-2019 (COVID-19). J Med Virol. 2020; 92:1845–1857
    1. Puelles VG, Lütgehetmann M, Lindenmeyer MT, et al. Multiorgan and renal tropism of SARS-CoV-2. N Engl J Med. 2020; 383:590–592

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