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Comment
. 2021 Aug;31(8):832-833.
doi: 10.1038/s41422-021-00512-x.

Host genetics, the microbiome & behaviour-a 'Holobiont' perspective

Jatin Nagpal  1 , John F Cryan  2   3
Affiliations
Comment

Host genetics, the microbiome & behaviour-a 'Holobiont' perspective

Jatin Nagpal et al. Cell Res. 2021 Aug.
No abstract available

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Conflict of interest statement

J.F.C has been an invited speaker at meetings organized by Mead Johnson, Yakult, Alkermes, and Abbott Nutrition and has received research funding from Cremo, IFF, Pharmavite and Nutricia. He has been a consultant for Alkermes and Nestle. J.N. has no competing interests to declare.

Figures

Fig. 1
Fig. 1. Host genetics and microbiota differentially regulate behaviors in the Cntnap2-/- mouse model of ASD.
The hyperactivity phenotype is caused by host genetics, whereas the social deficits are mediated by the gut microbiome. Selective administration of L. reuteri or the metabolite BH4 restores social behaviors, oxytocin levels and VTA plasticity. (The authors would like to thank P Venkata Atreya Sai for help with the illustration.)
See this image and copyright information in PMC

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References

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