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. 2021 Sep;51(9):e13584.
doi: 10.1111/eci.13584. Epub 2021 May 14.

Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations

Myunghee Hong  1 , Yusuke Ebana  2 , Jaemin Shim  3 , Eue-Keun Choi  4 , Hong Euy Lim  5 , Inseok Hwang  1 , Hee Tae Yu  1 , Tae-Hoon Kim  1 , Jae-Sun Uhm  1 , Boyoung Joung  1 , Seil Oh  4 , Moon-Hyoung Lee  1 , Young-Hoon Kim  3 , Sun Ha Jee  6 , Hui-Nam Pak  1
Affiliations

Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations

Myunghee Hong et al. Eur J Clin Invest. 2021 Sep.

Abstract

Background: In European ancestry, 111 genetic loci were identified as associated with atrial fibrillation (AF). We explored the reproducibility of those single nucleotide polymorphisms (SNPs) in a genome-wide association study (GWAS) meta-analysis of Far East Asian populations.

Methods: We performed a meta-analysis of the Korean AF network and Japanese AF data sets (9118 cases and 33 467 controls) by an inverse-variance fixed-effects model. We compared the results with 111 previously reported SNPs proven in Europeans after excluding 36 missing loci and a locus with a minor allelic frequency (MAF) < 0.01 in the European population.

Results: Among remaining 74 loci, 29 loci were replicated at a P < .05, and 17 of those loci were newly found in the Far East Asian population: 3 loci with a P < 5×10-8 (METTL11B at 1q24, KCNN2 at 5q22 and LRMDA at 10q22), 4 loci at the threshold of the Bonferroni correction of P = 4.5 × 10-4 ~ 5×10-8 (KIF3C at 2p23, REEP3, NRBF2 at 10q21, SIRT1, MYPN at 10q21 and CFL2 at 14q13) and 10 SNPs with a P = .05 ~ 4.5 × 10-4 . Among 18 AF loci with a MAF< 0.01 in the Far East Asian populations, 2 loci (GATA4 at 8q23 and SGCG at 13q12) were replicated after a fine mapping. Twenty-seven AF loci, including a locus, which had a sufficient sample size to get a power of over 80% (with a type 1 error α = 4.5 × 10-4 ), were not replicated in the Far East Asian populations.

Conclusions: We newly replicated 19 AF-associated genetic loci in the European descent among the Far East Asian populations. It highlights the extensive sharing of AF genetic risks across Far East Asian populations.

Keywords: Asian; atrial fibrillation; genetics; genome-wide association study; meta-analysis.

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References

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