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Meta-Analysis
. 2021 Jul;44(7):1151-1162.
doi: 10.1111/pace.14263. Epub 2021 May 24.

Feasibility, efficacy, and safety of ethanol infusion into the vein of Marshall for atrial fibrillation: A meta-analysis

Zhiyu He  1   2   3   4 , Lin Yang  5 , Ming Bai  1   3   4 , Yali Yao  1   3   4 , Zheng Zhang  1   2   3   4
Affiliations
Meta-Analysis

Feasibility, efficacy, and safety of ethanol infusion into the vein of Marshall for atrial fibrillation: A meta-analysis

Zhiyu He et al. Pacing Clin Electrophysiol. 2021 Jul.

Abstract

Background: Contemporary radiofrequency catheter ablation (RFCA) approaches for atrial fibrillation (AF) have reached an efficacy "ceiling". Ethanol infusion into the vein of Marshall (EI-VOM) has shown potential in preliminary studies. Data on EI-VOM are largely limited to small single-center reports, and clinical benefits and risks have not been systematically examined. Therefore, we performed a meta-analysis to assess the feasibility, efficacy, and safety of EI-VOM for AF.

Methods: All studies evaluating EI-VOM for AF were initially searched from four electronic search engines: PubMed, Web of Science, Cochrane Library, and SinoMed. We used RevMan5.4 to calculate pooled outcomes of randomized controlled trial and cohort studies. We also performed single-arm meta-analyses using Open Meta-Analyst.

Results: We included a total of 10 studies with 1322 patients. Successful EI-VOM was performed in 86.7% (95% CI 81.9-91.4%) of patients. For persistent AF patients, the recurrence of AF and/or atrial tachycardia (AT) was significantly lower in the EI-VOM combined with RFCA group compared with RFCA alone group (RR 0.58, 95% CI 0.35 to 0.96, p = 0.04). EI-VOM combined with RFCA significantly increased the rate of bidirectional mitral isthmus block compared with RFCA alone in AF patients (RR 1.50, 95% CI 1.34 to 1.67, p < 0.001). There were nine cardiac tamponades observed in 644 patients (PR 0.8%, 95% CI 0.1-1.5%) who were performed EI-VOM combined with RFCA.

Conclusions: Our meta-analysis brings encouraging evidence that adjuvant EI-VOM reduces AF and/or AT recurrence rate in persistent AF patients and increases the success rate of bidirectional mitral isthmus block.

Keywords: ablation; atrial fibrillation; ethanol infusion; vein of Marshall.

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References

REFERENCES

    1. Tilz RR, Heeger CH, Wick A, et al. Ten-year clinical outcome after circumferential pulmonary vein isolation utilizing the Hamburg approach in patients with symptomatic drug-refractory paroxysmal atrial fibrillation. Circ Arrhythm Electrophysiol. 2018;11:e005250.
    1. Dixit S, Marchlinski FE, Lin D, et al. Randomized ablation strategies for the treatment of persistent atrial fibrillation: rASTA study. Circ Arrhythm Electrophysiol. 2012;5:287-294.
    1. Verma A, Jiang CY, Betts TR, et al. Approaches to catheter ablation for persistent atrial fibrillation. The New England journal of medicine. 2015;372:1812-1822.
    1. Takigawa M, Derval N, Maury P, et al. Comprehensive multicenter study of the common isthmus in post-atrial fibrillation ablation multiple-loop atrial tachycardia. Circ Arrhythm Electrophysiol. 2018;11:e006019.
    1. Takigawa M, Derval N, Martin CA, et al. Mechanism of recurrence of atrial tachycardia: comparison between first versus redo procedures in a high-resolution mapping system. Circ Arrhythm Electrophysiol. 2020;13:e007273.

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