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Multicenter Study
. 2021 Aug;93(8):4805-4816.
doi: 10.1002/jmv.27085. Epub 2021 May 24.

Prevalence and genetic diversity of gastroenteritis viruses in hospitalized children < 5 years of age in Maharashtra state, Western India, 2017-2019

Varanasi Gopalkrishna  1 , Madhuri S Joshi  1 , Nutan A Chavan  1 , Manohar S Shinde  1 , Atul M Walimbe  2 , Pradeep M Sawant  1 , Vijay R Kalrao  3 , Ram K Dhongade  4 , Ashish R Bavdekar  5
Affiliations
Multicenter Study

Prevalence and genetic diversity of gastroenteritis viruses in hospitalized children < 5 years of age in Maharashtra state, Western India, 2017-2019

Varanasi Gopalkrishna et al. J Med Virol. 2021 Aug.

Abstract

Four gastroenteritis viruses were responsible for 54% of the acute gastroenteritis (AGE) cases in children hospitalized between May 2017 and December 2019 in Pune city of Maharashtra state, Western India. The majority (79%) of the children were <2 years of age. The prevalence of Rotavirus A (RVA) was 30.5% followed by 14.3% for norovirus, 8.4% for adenovirus, and 5.5% for astrovirus. The severity of the disease was highest in patients with coinfections compared with the patients with a single infection or negative for all (p = 0.024). Genotyping analysis showed that the majority of the RVA-positive samples (66%) could be typed as G3P[8], 63.6% of the norovirus as GII.4 Sydney [P16], 44% of the adenovirus as type 41%, and 56.2% of the astrovirus as astrovirus type 1. The almost equivalent prevalence of rotavirus and nonrotaviruses and acute gastroenteritis (AGE) cases without known etiology in around 46% of the cases was noted in the present study. Our data highlight that after the recent inclusion of rotavirus vaccines as a part of the National Immunization schedule in India, conducting extensive AGE surveillance in children should include nonrotaviruses such as norovirus.

Keywords: children; diarrhea; enteric viruses; genetic diversity; mixed infections; phylogenetic analysis; prevalence; rotavirus vaccine.

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References

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