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Comment
. 2021 Jul;7(7):577-579.
doi: 10.1016/j.trecan.2021.04.004. Epub 2021 May 13.

Retrotransposons: Jump to Cancer?

Yangjun Wu  1 , Xiaohua Wu  1 , Shengli Li  2
Affiliations
Comment

Retrotransposons: Jump to Cancer?

Yangjun Wu et al. Trends Cancer. 2021 Jul.

Abstract

Retrotransposons have been known as major sources of genomic instability that trigger and promote cancer development. In a recent study, Gu et al. revealed that MPP8 deficiency impeded tumor development through reactivation long interspersed element-1 (LINE-1 or L1) retrotransposons in acute myeloid leukemia (AML), suggesting a tumor-suppressive role for retrotransposons.

Keywords: LINE-1; leukemia; retrotransposon; tumor-suppressor.

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Conflict of interest statement

Declaration of Interests No interests are declared.

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