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Comment
. 2021 Aug;83(2):237-279.
doi: 10.1016/j.jinf.2021.05.009. Epub 2021 May 13.

Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection

Stephen Winchester  1 , Sarah John  2 , Kashif Jabbar  3 , Isaac John  4
Affiliations
Comment

Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection

Stephen Winchester et al. J Infect. 2021 Aug.

Abstract

Baek et al.1 investigated the duration of COVID-19 virus shedding in infected patients and demonstrated that even in patients demonstrating prolonged viral clearance, the virus was no longer viable after 15 days post onset of symptoms. Our study aimed to measure whether nitric oxide nasal spray (NONS) further accelerates this reduction in SARS-CoV-2 RNA load versus a control arm with saline spray. Our study recruited 80 participants who were divided into a NONS treatment arm or a placebo arm to test the efficacy of NONS as a treatment for mild COVID-19 infection.

Keywords: Antimicrobial; Antiviral; COVID-19; Coronavirus; Nasal Spray; Nitric oxide; Prevention; SARS-CoV-2; Treatment.

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Figures

Fig 1
Fig. 1
Mean Log(10) SARS-CoV-2 RNA at days 1 to 6 Shown is the difference in the change from baseline in SARS-CoV-2 RNA between the active (NONS) group and the placebo (saline) group from day 1 to day 6. The I bars represent standard error.
See this image and copyright information in PMC

Comment on

References

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