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. 2022 Feb 11;74(3):517-520.
doi: 10.1093/cid/ciab446.

BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity

Benoit Bailly  1   2 , Luc Guilpain  3 , Kevin Bouiller  2   4 , Catherine Chirouze  2   4 , Melissa N'Debi  5 , Alexandre Soulier  6 , Vanessa Demontant  5 , Jean-Michel Pawlotsky  6   7 , Christophe Rodriguez  5   6   7 , Slim Fourati  6   7
Affiliations

BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity

Benoit Bailly et al. Clin Infect Dis. .

Abstract

We report an outbreak of severe acute respiratory syndrome coronavirus 2 501Y.V2 in a nursing home. All nonvaccinated residents (5/5) versus half of those vaccinated with BNT162b2 (13/26) were infected. Two of 13 vaccinated versus 4 of 5 nonvaccinated residents presented severe disease. BNT162b2 did not prevent the outbreak, but reduced transmission and disease severity.

Keywords: BNT162b2 vaccine; SARS CoV-2; nursing home; outbreak; variant.

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