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. 2021 Dec 6;73(11):2112-2115.
doi: 10.1093/cid/ciab447.

Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents

David H Canaday  1   2 , Lenore Carias  1 , Oladayo A Oyebanji  1 , Debbie Keresztesy  1 , Dennis Wilk  1 , Michael Payne  1 , Htin Aung  1 , Kerri St Denis  3 , Evan C Lam  3 , Christopher F Rowley  4 , Sarah D Berry  5 , Cheryl M Cameron  1 , Mark J Cameron  1 , Brigid Wilson  2 , Alejandro B Balazs  3 , Stefan Gravenstein  6   7 , Christopher L King  1   8
Affiliations

Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents

David H Canaday et al. Clin Infect Dis. .

Abstract

After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-naive nursing home residents' median post-second vaccine dose antibody neutralization titers are one-quarter that of SARS-CoV-2-naive healthcare workers.

Keywords: COVID-19; SARS-CoV-2; geriatrics; vaccine.

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Figures

Figure 1.
Figure 1.
Humoral immune assessment of BNT162b2 messenger RNA (mRNA) vaccine vaccination in nursing home (NH) residents. Postvaccination anti-spike, anti–receptor-binding domain (RBD) and serum neutralization titers are shown. On the x-axis, “NH” refers to NH residents and “control” refers to the vaccinated younger healthcare workers or unvaccinated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–convalescent individuals. The dotted line in each panel is the median preimmunization value in the SARS-CoV-2–naive subjects. Anti-spike and anti-RBD differences in geometric means were assessed using t tests of log-transformed values. Given observed points at upper and lower limits of detection in the neutralizing titer assay (12–8748), differences in distribution were assessed using the Wilcoxon rank-sum test. P values were adjusted within assay (n = 6 tests per assay, Bonferroni method). ***Adjusted P < .001. Abbreviations: AU, antibody unit; NH, nursing home; pNT50, pseudovirus neutralization titer.
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