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Meta-Analysis
. 2022 Apr;52(4):1568-1586.
doi: 10.1007/s10803-021-05046-0. Epub 2021 May 15.

Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis

Julio Vaquerizo-Serrano  1   2   3 , Gonzalo Salazar de Pablo  1   3   4 , Jatinder Singh  1   2 , Paramala Santosh  5   6
Affiliations
Meta-Analysis

Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis

Julio Vaquerizo-Serrano et al. J Autism Dev Disord. 2022 Apr.

Abstract

Psychotic experiences can occur in autism spectrum disorders (ASD). Some of the ASD individuals with these experiences may fulfil Clinical High-Risk for Psychosis (CHR-P) criteria. A systematic literature search was performed to review the information on ASD and CHR-P. A meta-analysis of the proportion of CHR-P in ASD was conducted. The systematic review included 13 studies. The mean age of ASD individuals across the included studies was 11.09 years. The Attenuated Psychosis Syndrome subgroup was the most frequently reported. Four studies were meta-analysed, showing that 11.6% of CHR-P individuals have an ASD diagnosis. Symptoms of prodromal psychosis may be present in individuals with ASD. The transition from CHR-P to psychosis is not affected by ASD.

Keywords: Autism spectrum disorders; Clinical high-risk for psychosis; Meta-analysis; Prodromal psychosis; Psychosis; Systematic review.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram
Fig. 2
Fig. 2
Meta-analysis: ASD in CHR-P. Forest plot
See this image and copyright information in PMC

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