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Review
. 2021 Apr;48(4):3845-3851.
doi: 10.1007/s11033-021-06196-1. Epub 2021 May 15.

Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle

Maryam Abolghasemi  1   2   3 , Soleiman Mahjoub  4   5
Affiliations
Review

Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle

Maryam Abolghasemi et al. Mol Biol Rep. 2021 Apr.

Abstract

Polycystic ovary syndrome (PCOS) is an endocrine disorder and affects 5-10% of reproductive-age women. Chronic anovulation, polycystic ovaries, and hyperandrogenism are the important features of this syndrome. Furthermore, hyperinsulinemia and central obesity are frequent in PCOS women. In recent years, noncoding RNAs detection provided new ideas to explain the etiology of female reproductive disorders. Long noncoding RNAs (lncRNAs) as a subset of noncoding RNAs are associated with the pathogenesis of manifold reproductive-related disorders. Various investigations emphasized the potential involvement of lncRNAs in PCOS development. Therefore, in this paper, we will summarize the function of numerous lncRNAs in the apoptosis and proliferation of granulosa cells (GCs), insulin resistance (IR), and steroidogenesis in PCOS.

Keywords: Granulosa cell; Hyperandrogenism; Insulin resistance; Polycystic ovary syndrome; lncRNA.

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