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Review
. 2022 Jul;289(13):3642-3654.
doi: 10.1111/febs.16017. Epub 2021 May 31.

MARCH8: the tie that binds to viruses

Takuya Tada  1   2 , Yanzhao Zhang  1 , Hideaki Fujita  3 , Kenzo Tokunaga  1
Affiliations
Free article
Review

MARCH8: the tie that binds to viruses

Takuya Tada et al. FEBS J. 2022 Jul.
Free article

Abstract

Membrane-associated RING-CH (MARCH) family member proteins are RING-finger E3 ubiquitin ligases that are known to downregulate cellular transmembrane proteins. MARCH8 is a novel antiviral factor that inhibits HIV-1 envelope glycoprotein and vesicular stomatitis virus G by downregulating these envelope glycoproteins from the cell surface, resulting in their reduced incorporation into virions. More recently, we have found that MARCH8 reduces viral infectivity via two different mechanisms. Additionally, several groups have reported further antiviral or virus-supportive functions of the MARCH8 protein and its other cellular mechanisms. In this review, we summarize the current knowledge about the molecular mechanisms by which MARCH8 can regulate cellular homeostasis and inhibit and occasionally support enveloped virus infection.

Keywords: MARCH8; antiviral factor; downregulation; transmembrane protein; viral envelope.

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References

    1. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K & Fruh K (2004) Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol 78, 1109-1120.
    1. Goto E, Ishido S, Sato Y, Ohgimoto S, Ohgimoto K, Nagano-Fujii M & Hotta H (2003) c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. J Biol Chem 278, 14657-14668.
    1. Stevenson PG, Efstathiou S, Doherty PC & Lehner PJ (2000) Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses. Proc Natl Acad Sci USA 97, 8455-8460.
    1. Ishido S, Wang C, Lee BS, Cohen GB & Jung JU (2000) Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. J Virol 74, 5300-5309.
    1. Coscoy L & Ganem D (2000) Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc Natl Acad Sci USA. 97, 8051-8056.

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