Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jul;78(1):94-103.
doi: 10.1161/HYPERTENSIONAHA.121.17248. Epub 2021 May 17.

Adrenocorticotropic Hormone-Stimulated Adrenal Venous Sampling Underestimates Surgically Curable Primary Aldosteronism: A Retrospective Cohort Study and Review of Contemporary Studies

Nicholas Yozamp  1 , Gregory L Hundemer  2 , Marwan Moussa  3 , Jonathan Underhill  3 , Tali Fudim  3 , Barry Sacks, Anand Vaidya  1
Affiliations
Review

Adrenocorticotropic Hormone-Stimulated Adrenal Venous Sampling Underestimates Surgically Curable Primary Aldosteronism: A Retrospective Cohort Study and Review of Contemporary Studies

Nicholas Yozamp et al. Hypertension. 2021 Jul.

Abstract

[Figure: see text].

Keywords: adrenocorticotropic hormone; catheterization; consensus; interventional radiology; treatment outcome.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Waterfall plot demonstrating the percent change in lateralization index following ACTH stimulation.
Each individual patient’s change in lateralization index following ACTH stimulation is represented on the x-axis in order of the magnitude of the change. The y-axis represents the log-scale of the percent change in the lateralization index following ACTH stimulation.
Figure 2.
Figure 2.. Baseline (pre-ACTH) vs Stimulated (post-ACTH) Lateralization Indices.
Box-and-whisker plot of the average pre-ACTH LI across all 340 patients compared to the average post-ACTH LI across all patients. Medians used for comparison given strongly positive skew, particularly with post-ACTH values.
See this image and copyright information in PMC

References

    1. Vaidya A, Mulatero P, Baudrand R, Adler GK. The Expanding Spectrum of Primary Aldosteronism: Implications for Diagnosis, Pathogenesis, and Treatment. Endocr Rev. 2018;39(6):1057–1088. doi:10.1210/er.2018-00139 - DOI - PMC - PubMed
    1. Monticone S, Burrello J, Tizzani D, Bertello C, Viola A, Buffolo F, Gabetti L, Mengozzi G, Williams TA, Rabbia F, Veglio F, Mulatero P. Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice. J Am Coll Cardiol. 2017;69(14):1811–1820. doi:10.1016/j.jacc.2017.01.052 - DOI - PubMed
    1. Rossi GP, Bernini G, Caliumi C, Desideri G, Fabris B, Ferri C, Ganzaroli C, Giacchetti G, Letizia C, Maccario M, et al. A Prospective Study of the Prevalence of Primary Aldosteronism in 1,125 Hypertensive Patients. J Am Coll Cardiol. 2006;48(11):2293–2300. doi:10.1016/j.jacc.2006.07.059 - DOI - PubMed
    1. Brown JM, Siddiqui M, Calhoun DA, Carey RM, Hopkins PN, Williams GH, Vaidya A. The Unrecognized Prevalence of Primary Aldosteronism: A Cross-sectional Study. Ann Intern Med. 2020;173(1):10–20. doi:10.7326/M20-0065 - DOI - PMC - PubMed
    1. Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H, Stowasser M, Young WF. The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(5):1889–1916. doi:10.1210/jc.2015-4061 - DOI - PubMed

Publication types