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. 2021 May 17;3(1):28.
doi: 10.1186/s42466-021-00127-y.

Chronic intracranial hypertension after cerebral venous and sinus thrombosis - frequency and risk factors

Christina Geisbüsch  1 , Christian Herweh  2 , Christoph Gumbinger  1 , Peter A Ringleb  1 , Markus A Möhlenbruch  2 , Simon Nagel  3
Affiliations

Chronic intracranial hypertension after cerebral venous and sinus thrombosis - frequency and risk factors

Christina Geisbüsch et al. Neurol Res Pract. .

Abstract

Background: Cerebral venous sinus thrombosis (CVST) can infrequently lead to chronical intracranial hypertension (IH) due to the altered venous drainage. The aim of this study was to ascertain the risk of IH after CVST and to stratify underlying risk factors.

Methods: We performed a retrospective cohort analysis of all cases treated for acute CVST at our department between 2013 and 2019. IH was diagnosed at follow-up according to the modified Dandy criteria. CVST-patients with and without IH were descriptively compared conforming to available clinical and radiological data as well as outcomes.

Results: Our study included 102 patients with acute CVST. In 70 cases complete follow-up data was available (68.6%). Seven of these patients developed symptomatic intracranial hypertension (10%; N = 7, n = 70) within a median follow-up of 6 months. Four of these patients (57.1% (N = 4, n = 7) vs. 3.2% (N = 2, n = 63); p < 0.001) presented recurrent sinus thrombosis in the further course. There were no significant differences between patients with or without IH concerning gender, age, risk factors, occluded vessels and treatment for their CVST. However the presence of visual deterioration at initial admission was higher in patients who developed IH afterwards (57.1% (N = 4, n = 7) vs. 20.6% (N = 13, n = 63); p = 0.03). Patients with chronic IH after CVST showed significantly less likely recanalization of the occluded vessel on follow-up MRI (no recanalization in 28.6% (N = 2, n = 7) vs. 4.8% (N = 3, n = 63); p = 0.02). All patients with IH had a good outcome (mRS 0-2) at discharge and follow-up.

Conclusion: IH occurred in around 10% after CVST. Insufficient recanalization status may facilitate IH. Patients with visual disturbances seem to develop more likely IH afterwards. Patients who present IH after CVST may develop recurrent cerebral venous thrombosis.

Keywords: Cerebral venous and sinus thrombosis; Intracranial hypertension; Visual impairment.

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Conflict of interest statement

Christina Geisbüsch—none.

Christian Herweh—UNRELATED: Consultancy: Brainomix, Oxford, UK,

Christoph Gumbinger—UNRELATED: Speaker of the commission teleneurology service of the German Stroke Society.

Peter A. Ringleb—UNRELATED: Consultancy: Boehringer, Lecture fees from Bayer, Boehringer Ingelheim, BMS, Daichii Sankyo, Pfizer.

Markus A. Möhlenbruch—UNRELATED: Board Membership: Codman; Consultancy: Medtronic, MicroVention, Stryker; Payment for Lectures Including Service on Speakers Bureaus: Medtronic, MicroVention, Stryker. *Money paid to the institution.

Simon Nagel—UNRELATED: Consultancy: Brainomix, Boehringer Ingelheim; Payment for Lectures Including Service on Speakers Bureaus: Pfizer, Medtronic, Bayer AG.

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