Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct;32(10):750-751.
doi: 10.1016/j.tem.2021.05.001. Epub 2021 May 13.

Stress-induced muscle-to-CNS signaling

Nikolai P Jaschke  1 , Sophie Paehlig  2 , Tilman D Rachner  2
Affiliations

Stress-induced muscle-to-CNS signaling

Nikolai P Jaschke et al. Trends Endocrinol Metab. 2021 Oct.

Abstract

Soluble mediators secreted by skeletal muscles (collectively referred to as myokines) exert systemic effects by signaling to distant organs. Rai et al. have now uncovered a muscle-to-central nervous system (CNS) signaling axis, which is engaged in response to proteostatic stress. These adaptations confer protection against pathological protein accumulation in the CNS, a hallmark of neurodegenerative diseases.

PubMed Disclaimer

Publication types