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Review
. 2021;27(3):254-256.
doi: 10.1007/s12268-021-1576-6. Epub 2021 May 11.

SARS-CoV-PLpro-Inhibitoren als mögliche Breitspektrum-Virostatika

[Article in German]
Stefan Josef Hammerschmidt  1 , Patrick Müller  1 , Tanja Schirmeister  1
Affiliations
Review

SARS-CoV-PLpro-Inhibitoren als mögliche Breitspektrum-Virostatika

[Article in German]
Stefan Josef Hammerschmidt et al. Biospektrum (Heidelb). 2021.

Abstract

The SARS-CoV-encoded papain-like cysteine protease (PLpro) plays crucial roles in viral replication and maturation processes. It is required to cleave the precursor polyproteins into functional proteins. Thus, it is considered to be a promising target for developing specific drugs. For rational optimization of hit compounds, information about the structure-activity relationship (SAR) is fundamental. Herein, we characterize isoindolines as a new class of PLpro inhibitors.

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References

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