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Review
. 2021 Apr;12(Suppl 1):57-64.
doi: 10.1007/s13193-019-01008-2. Epub 2019 Nov 16.

Molecular Oncology of Gall Bladder Cancer

Arun Chaturvedi  1 , Vijay Kumar  1 , Sameer Gupta  1
Affiliations
Review

Molecular Oncology of Gall Bladder Cancer

Arun Chaturvedi et al. Indian J Surg Oncol. 2021 Apr.

Abstract

Gall bladder carcinoma (GBC) is a worldwide problem, with a higher incidence in areas of the world where cholelithiasis is common. As GBC is usually diagnosed in an advanced stage, the mortality is high. An understanding of the molecular pathways of carcinogenesis and the mutations involved in the development and progression of GBC could be useful in early diagnosis. Understanding molecular markers of prognosis as well as predictors of outcome could also potentially benefit patients undergoing treatment. New therapies targeting major molecular pathways and immunotherapy are exciting novel therapeutic options. This review focuses on the current understanding of the molecular oncology of GBC.

Keywords: Biliary cancers; Gall bladder carcinoma; Immunotherapy; Molecular oncology; Mutations; Targeted therapy.

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Conflict of interest statement

Conflict of InterestThe authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Pathways of gallbladder carcinoma pathogenesis
See this image and copyright information in PMC

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References

    1. Are C, Ahmad H, Ravipati A, Croo D, Clarey D, Smith L, Price RR, Butte JM, Gupta S, Chaturvedi A, Chowdhury S. Global epidemiological trends and variations in the burden of gallbladder cancer. J Surg Oncol. 2017;115(5):580–590. - PubMed
    1. Randi G, Franceschi S, la Vecchia C. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006;118(7):1591–1602. - PubMed
    1. Park YK, Kim SW, Park YH. A clinical study of gallbladder carcinoma. Korean J Gastroenterol. 1989;21:113–122.
    1. Kimura K, Ohto M, Saisho H, Unozawa T, Tsuchiya Y, Morita M, Ebara M, Matsutani S, Okuda K. Association of gallbladder carcinoma and anomalous pancreaticobiliary ductal union. Gastroenterology. 1985;89:1258–1265. - PubMed
    1. Wistuba Ignacio I, GazdarAdi F. Gallbladder cancer: lessons from a rare tumor. Nat Rev Cancer. 2004;4:695–706. - PubMed

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