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Review
. 2021 Apr;12(Suppl 1):152-163.
doi: 10.1007/s13193-020-01253-w. Epub 2020 Oct 28.

Prevalence of Molecular Subtypes of Breast Cancer in India: a Systematic Review and Meta-analysis

Pavan Kumar Jonnada  1 , Cherukuru Sushma  2 , Madhuri Karyampudi  3 , Anvesh Dharanikota  1
Affiliations
Review

Prevalence of Molecular Subtypes of Breast Cancer in India: a Systematic Review and Meta-analysis

Pavan Kumar Jonnada et al. Indian J Surg Oncol. 2021 Apr.

Abstract

In the last two decades, India has witnessed a substantial increase in the incidence of breast cancer and associated mortality. Studies on the prevalence of molecular subtypes of breast cancer in India have reported inconsistent results. Therefore, we conducted a systematic review of observational studies to document the prevalence of molecular subtypes of breast cancer. A complete literature search for observational studies was conducted in MEDLINE and EMBASE databases using key MeSH terms ((molecular classification) OR (molecular subtypes)) AND (breast cancer)) OR (breast carcinoma)) AND (prevalence)) AND (India). Two reviewers independently reviewed the retrieved studies. The screened studies satisfying the eligibility were included. The quality of included studies was assessed using the selected STROBE criteria. The overall pooled prevalence of luminal A, luminal B, HER2-enriched, and triple-negative breast cancer (TNBC) subtypes of breast cancer were 0.33 (95% CI 0.23-0.44), 0.17 (95% CI 0.12-0.23), 0.15 (95% CI 0.12-0.19), and 0.30 (95% CI 0.27-0.33), respectively. Subgroup analyses were performed by mean age of patients, time period, region, and sample size of the study. Among molecular subtypes of breast cancer, luminal A was the most prevalent subtype followed by TNBC, luminal B, and HER2-enriched subtypes. The overall prevalence of TNBC in India is high compared to other regions of the world. Additional research is warranted to identify the determinants of high TNBC in India. Differentiating TNBC from other molecular subtypes is important to guide therapeutic management of breast cancer.

Keywords: Breast cancer; HER2; Triple-negative breast cancers.

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Figures

Fig. 1
Fig. 1
PRISMA diagram
Fig. 2
Fig. 2
Forest plot of luminal A tumors
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Fig. 3
Forest plot of luminal B tumors
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Fig. 4
Forest plot of HER2/neu-enriched tumors
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Fig. 5
Forest plot of triple-negative breast cancers
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Fig. 6
Forest plot of hormone-positive breast cancers
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Fig. 7
Forest plot of HER2/neu-positive breast cancers
Fig. 8
Fig. 8
Funnel plot of molecular subtypes of breast cancer
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Printzcancer C. Breast cancer mortality rates decline internationally, with some major exceptions. Cancer. 2017;123:1085. - PubMed
    1. Weigelt B, Baehner FL, Reis-Filho JS. The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade. J Pathol. 2010;220:263–280. - PubMed
    1. Perou CM, Sørlie T, Eisen MB. Molecular portraits of human breast tumours. Nature. 2000;406:747–752. - PubMed
    1. Asthana S, Chauhan S, Labani S. Breast and cervical cancer risk in India: an update. Indian J Public Health. 2014;58:5–10. - PubMed

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