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Case Reports
. 2021 Apr;12(Suppl 1):193-196.
doi: 10.1007/s13193-021-01284-x. Epub 2021 Feb 3.

Solitary Pancreatic Head Metastasis from Ductal Carcinoma of Breast: A Case Report

Parag Ingle  1 , Pravin Khandare  2 , Manjit Rajput  3 , Megha Tiwari  4 , Mangesh Patil  5 , Ajay Mehta  1
Affiliations
Case Reports

Solitary Pancreatic Head Metastasis from Ductal Carcinoma of Breast: A Case Report

Parag Ingle et al. Indian J Surg Oncol. 2021 Apr.

Abstract

Liver, bones, and brain are common sites for breast cancer metastasis. We report here a rare scenario of metastasis to pancreatic head from breast cancer after a disease free interval of 7 years. A 60-year old breast cancer survivor noticed upper abdominal pain for 2 weeks, and her investigations revealed a pancreatic head mass lesion. Computed tomography imaging revealed a solitary pancreatic mass lesion with portal cavernoma formation and a guided biopsy yielded adenocarcinoma on histopathological examination. Immunohistochemistry processing demonstrated estrogen receptor, cytokeratin 7, and GATA 3 positivity which confirmed it to be a metastasis. Therapy was initiated with palbociclib and exemestane. Later, everolimus was started in view of failure of hormonal therapy. The patient is still alive 21 months after diagnosing the recurrence.

Keywords: Breast cancer; Estrogen receptor; Palbociclib; Pancreatic metastasis.

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Figures

Fig. 1
Fig. 1
Axial CT image showing head of pancreas mass with multiple venous collaterals due to encasement of portal vein
Fig. 2
Fig. 2
Coronal CT image showing pancreatic head mass with abutment of common hepatic artery
Fig. 3
Fig. 3
Photomicrograph showing ER positivity of tumor cells by immunohistochemistry
Fig. 4
Fig. 4
Photomicrograph showing GATA3 positivity of tumor cells by immunohistochemistry
See this image and copyright information in PMC

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