doi: 10.1073/pnas.85.15.5355.
Catalysis of a stereospecific bimolecular amide synthesis by an antibody
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- PMID: 3399496
- PMCID: PMC281754
- DOI: 10.1073/pnas.85.15.5355
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Catalysis of a stereospecific bimolecular amide synthesis by an antibody
Proc Natl Acad Sci U S A.
1988 Aug.
Abstract
We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.
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