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. 1988 Aug;85(15):5355-8.
doi: 10.1073/pnas.85.15.5355.

Catalysis of a stereospecific bimolecular amide synthesis by an antibody

S J Benkovic  1 , A D Napper, R A Lerner
Affiliations

Catalysis of a stereospecific bimolecular amide synthesis by an antibody

S J Benkovic et al. Proc Natl Acad Sci U S A. 1988 Aug.

Abstract

We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

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