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. 2021 Jan-Feb;12(1):79-88.
doi: 10.32598/bcn.12.1.941.6. Epub 2021 Jan 1.

Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development

Mona Zamanian Azodi  1 , Mostafa Rezaei Tavirani  1 , Majid Rezaei Tavirani  2 , Mohammad Rostami Nejad  3
Affiliations

Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development

Mona Zamanian Azodi et al. Basic Clin Neurosci. 2021 Jan-Feb.

Abstract

Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics.

Methods: In this study, a gene expression profile from a microarray study was selected for more investigation.

Results: The study of Down syndrome patients shows specific genes with differential expression and network centrality properties. These genes are introduced as RHOA, FGF2, FYN, and CD44, and their level of expression is high in these patients.

Conclusion: This study suggests that besides chromosomes 21, there are additional contributing chromosomes to the risk of Down syndrome development. Besides, these genes could be used for clinical studies after more analysis.

Keywords: Biological Process; Differentially Expressed Genes; Down Syndrome; Protein interaction Maps; Transcriptome.

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Conflict of interest statement

Conflict of interest The authors declared no conflict of interest.

Figures

Figure 1.
Figure 1.
Graphical view of value distribution in 8 healthy and 7 DS cases via boxplot analysis. Blue color indicates control samples while pink color indicates DS samples Lateral axis: Names of samples; Longitudinal axis: The genes.
Figure 2.
Figure 2.
Normalized expression showing as node labels for 18 found genes using DS profile
Figure 3.
Figure 3.
Action type analysis of the four significant central DEGs (differentially expressed genes) via CluePedia exploration
Figure 4.
Figure 4.
Biological process examination of the four significant expressed hub-bottlenecks in Down syndrome via ClueGO+ CluePedia
See this image and copyright information in PMC

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