Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Fall;11(Suppl 1):S30-S36.
doi: 10.34172/jlms.2020.S5. Epub 2020 Dec 30.

Role of Flt4 in Skin Protection against UVB Radiation: A System Biology Approach

Babak Arjmand  1 , Mostafa Rezaei Tavirani  2 , Mohammadreza Razzaghi  3 , Mohammad Rostami-Nejad  4 , Mostafa Hamdieh  5 , Abdolrahim Nikzamir  6
Affiliations

Role of Flt4 in Skin Protection against UVB Radiation: A System Biology Approach

Babak Arjmand et al. J Lasers Med Sci. 2020 Fall.

Abstract

Background: Although the application of ultraviolet B (UVB) in phototherapy of human skin is a common therapeutic method, it is known as a risk factor for skin cancer. This study aims to assess the role of differentially expressed genes (DEGs) to find the critical one that is mainly responsible for skin protection against UVB radiation. Methods: The gene expression profiles of irradiated mice by UVB that issued skin protection against exposure are extracted from Gene Expression Omnibus (GEO) and analyzed by GEO2R. The significant DEGs are assessed via gene ontology (GO) analysis and the critical individuals are investigated via action mapping. Results: Thirty-eight significant DEGs that provide skin resistance against UVB irradiation were determined. Among the query DEGs, 26 individuals were related to 43 biological terms. Flt4, F3, Tspan6, Cblb, and Itgb6 were highlighted as the critical DEGs to promote skin protection against UVB irradiation. Conclusion: The finding indicates that Flt4 is the key DEG that is mainly responsible for protecting skin from UVB exposure.

Keywords: Flt4; Gene ontology; Mouse; Skin; UVB.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Figure 2
Figure 2
Figure 3
Figure 3
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. De Gruijl FR. Skin cancer and solar UV radiation. Eur J Cancer. 1999;35(14):2003–9. doi: 10.1016/S0959-8049(99)00283-X. - DOI - PubMed
    1. Bode AM, Dong Z. Mitogen-activated protein kinase activation in UV-induced signal transduction. Sci Signal. 2003;2003(167):re2. doi: 10.1126/stke.2003.167.re2. - DOI - PubMed
    1. Pasker-de Jong PC, Wielink G, van der Valk PG, van der Wilt GJ. Treatment with UV-B for psoriasis and nonmelanoma skin cancer: a systematic review of the literature. Arch Dermatol. 1999;135(7):834–40. doi: 10.1001/archderm.135.7.834. - DOI - PubMed
    1. Scherschun L, Kim JJ, Lim HW. Narrow-band ultraviolet B is a useful and well-tolerated treatment for vitiligo. J Am Acad Dermatol. 2001;44(6):999–1003. doi: 10.1067/mjd.2001.114752. - DOI - PubMed
    1. Ramsay DL, Lish KM, Yalowitz CB, Soter NA. Ultraviolet-B phototherapy for early-stage cutaneous T-cell lymphoma. Arch Dermatol. 1992;128(7):931–3. - PubMed

LinkOut - more resources