Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Fall;11(Suppl 1):S67-S72.
doi: 10.34172/jlms.2020.S11. Epub 2020 Dec 30.

The Effect of Carbon Dioxide Laser on Aphthous stomatitis Treatment: A Double-Blind Randomized Clinical Trial

Seyyed Amir Seyyedi  1 , Pooya Olyaee  2 , Reza Fekrazad  3 , Sanaz Partovi  4 , Maryam Baghizadeh Fini  5   6
Affiliations

The Effect of Carbon Dioxide Laser on Aphthous stomatitis Treatment: A Double-Blind Randomized Clinical Trial

Seyyed Amir Seyyedi et al. J Lasers Med Sci. 2020 Fall.

Abstract

Introduction: This randomized clinical trial was designed to investigate the effect of carbon dioxide laser on the treatment of minor recurrent aphthous stomatitis (miRAS) as a painful and common oral ulcer. Methods: Fifteen patients with miRAS entered into this study after compliance with the inclusion and exclusion criteria. The patients were assigned to three groups of pulsed CO2 laser, continuous CO2 laser, and control. A pulsed CO2 laser with power of 261 W and pulse duration of 180 microseconds and continuous CO2 lasers with the power of 1 W and radiation duration of 5-10 seconds were used. In the control group, topical triamcinolone ointment of 0.1% was used. The degree of pain was measured using the visual analogue scale (VAS). The patients were evaluated in terms of pain intensity before and immediately after the treatment and at follow-up hours, 12, 24, 48, and 72 hours after the intervention, and changes in the size of the ulcers were measured before the treatment and on third, fifth, and seventh days. Results: The effect of CO2 laser with pulsed and continuous radiation on the pain intensity of aphthous lesions, immediately after the treatment and at subsequent follow-up hours were similar and even better than the control group (P<0.05). All three treatments had a similar effect on the size of the ulcer, which was not statistically significant (P>0.05). Conclusion: The results of this randomized controlled trial (RCT) showed that the carbon dioxide laser, whether with pulsed radiation or continuous radiation compared to the control group, had a better impact on the pain relief of aphthous lesions.

Keywords: Carbon dioxide lasers; Laser; Pain; Recurrent aphthous stomatitis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Figure 2
Figure 2
Figure 3
Figure 3
See this image and copyright information in PMC

References

    1. Greenberg MS, Glick M, Ship JA. Burket’s Oral Medicine. 11th ed. Hamilton, Canada: BC Decker Inc; 2008.
    1. Zand N, Ataie-Fashtami L, Djavid GE, Fateh M, Alinaghizadeh MR, Fatemi SM. et al. Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation. Lasers Med Sci. 2009;24(4):515–520. doi: 10.1007/s10103-008-0555-1. - DOI - PubMed
    1. Shashy RG, Ridley MB. Aphthous ulcers: A difficult clinical entity. Am J Otolaryngol. 2000;21(6):389–393. doi: 10.1053/ajot.2000.18872. - DOI - PubMed
    1. Regezi JA, Sciubba J, Jordan RC. Oral Pathology: Clinical Pathologic Correlations. 6th ed. St. Louis: Saunders; 2012.
    1. Neville BW, D. Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. St. Louis: Saunders; 2008.

LinkOut - more resources