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Editorial
. 2021 May 3;10(1):1918373.
doi: 10.1080/2162402X.2021.1918373.

A bacterium-derived, cancer-associated immunopeptidome

Claude Perreault  1 , Pierre Thibault  1 , Guido Kroemer  2   3   4   5   6
Affiliations
Editorial

A bacterium-derived, cancer-associated immunopeptidome

Claude Perreault et al. Oncoimmunology. .
No abstract available

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Figures

Figure 1.
Figure 1.
Hypothetical relationship between intracellular bacteria, the expression of MHC class-I- restricted epitopes on the surface of infected tumor cells and immunosurveillance by cytotoxic T lymphocytes eliminating infected tumor cells. In the real-life situation, in patients with metastatic melanoma, a minor fraction of tumor cells contains bacteria (middle panel). It will be interesting to know whether local immunosuppression may shift the balance to a more intense bacterial infection or whether, on the contrary, improved T cell responses against bacterium-encoded epitopes (symbolized by triangles) can eradicate infected tumor cells
See this image and copyright information in PMC

Comment on

  • Identification of bacteria-derived HLA-bound peptides in melanoma.
    Kalaora S, Nagler A, Nejman D, Alon M, Barbolin C, Barnea E, Ketelaars SLC, Cheng K, Vervier K, Shental N, Bussi Y, Rotkopf R, Levy R, Benedek G, Trabish S, Dadosh T, Levin-Zaidman S, Geller LT, Wang K, Greenberg P, Yagel G, Peri A, Fuks G, Bhardwaj N, Reuben A, Hermida L, Johnson SB, Galloway-Peña JR, Shropshire WC, Bernatchez C, Haymaker C, Arora R, Roitman L, Eilam R, Weinberger A, Lotan-Pompan M, Lotem M, Admon A, Levin Y, Lawley TD, Adams DJ, Levesque MP, Besser MJ, Schachter J, Golani O, Segal E, Geva-Zatorsky N, Ruppin E, Kvistborg P, Peterson SN, Wargo JA, Straussman R, Samuels Y. Kalaora S, et al. Nature. 2021 Apr;592(7852):138-143. doi: 10.1038/s41586-021-03368-8. Epub 2021 Mar 17. Nature. 2021. PMID: 33731925 Free PMC article.

References

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