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Case Reports
. 2021 Apr 21:32:73-76.
doi: 10.1016/j.mmcr.2021.04.002. eCollection 2021 Jun.

First report of human infection caused by Colletotrichum chlorophyti occurring in a post-corneal transplant patient with endophthalmitis

Alberto E Paniz-Mondolfi  1 , Steven Agemy  2 , Connie Cañete-Gibas  3 , Melissa R Gitman  1 , Codrin E Iacob  3 , Inna Necula  1 , Ching-Yi Wang  1 , Lourdes A Delgado Noguera  4 , Carmita Sanders  5 , Nathan P Wiederhold  5 , Emilia M Sordillo  1 , Michael D Nowak  1
Affiliations
Case Reports

First report of human infection caused by Colletotrichum chlorophyti occurring in a post-corneal transplant patient with endophthalmitis

Alberto E Paniz-Mondolfi et al. Med Mycol Case Rep. .

Abstract

Keratomycosis or mycotic keratitis is recognized as one of the major causes of ophthalmic morbidity worldwide. The most common organisms linked to keratomycosis include Candida spp., Fusarium spp., and Aspergillus spp. However, varieties of saprobic fungi have been reported as causative agents of keratomycosis. Amongst these are members of the genus Colletotrichum. Herein we present the first reported case of C. chlorophyti infection in a post-corneal transplant patient, suggesting an increasing role for Colletotrichum species as emerging human pathogens, particularly in the transplant population.

Keywords: Colletotrichum chlorophyti; Emerging; Fungal; Keratitis; Pathogen.

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Conflict of interest statement

The authors declare not to have any conflict of interest.

Figures

Fig. 1
Fig. 1
Fungal keratitis (a–d). Periodic acid–Schiff (PAS)–depicting fungal elements (a). Higher magnification showing multiple hyphae (PAS, original magnification × 100) and numerous infiltrating eosinophils (b). Grocott-Gomori methenamine-silver (GMS) stain highlighting fungal elements (c). Branching hyphae throughout the corneal stroma (GMS, original magnification ×100).
Fig. 2
Fig. 2
Colletotrichum chlorophyti (from UTHSCSA DI19-239 isolate): colony on MEA at 25 °C: 5d, (a) reverse - (b) obverse; 7d, (c) reverse - (d) obverse; (e–f) chlamydospores (arrow); (g) appressoria (arrow); (h) conidia (white arrow), conidiophore (black arrow). e: from Sabouraud dextrose agar (SDA), f-h from PFA, 14d at 25 °C.
See this image and copyright information in PMC

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