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Review
. 2021 Sep;10(3):100726.
doi: 10.1016/j.imr.2021.100726. Epub 2021 Apr 2.

Chinese patent herbal medicine (Shufeng Jiedu capsule) for acute upper respiratory tract infections: A systematic review and meta-analysis

Ying-Ying Zhang  1 , Ru-Yu Xia  1 , Shi-Bing Liang  1 , Xiao-Yang Hu  2 , Meng-Yuan Dai  3 , Yi-Lin Li  4 , Le-Yi Zhao  4 , Michael Moore  2 , Yu-Tong Fei  1 , Jian-Ping Liu  1
Affiliations
Review

Chinese patent herbal medicine (Shufeng Jiedu capsule) for acute upper respiratory tract infections: A systematic review and meta-analysis

Ying-Ying Zhang et al. Integr Med Res. 2021 Sep.

Abstract

Background: Shufeng Jiedu capsule has been widely used in China for acute upper respiratory tract infections (AURTIs). The aim of this study was to evaluate its effectiveness and safety for AURTIs.

Methods: Randomized controlled trials comparing SFJD with conventional drug for patients with AURTIs were included. Eight databases were searched from their inceptions to February 2021. Data was synthesized using risk ration (RR) or mean difference (MD) with their 95% confidence interval (CI). The primary outcome was resolution time of typical symptoms.

Results: Twenty-five RCTs involving 3410 patients were included. SFJD in combination with conventional drug was associated with; in common cold shortening the duration of fever (MD -1.54 days, 95% CI [-2.15,-0.92], I 2 = 80%, n = 385, 3 trials) and cough (MD -1.22 days, 95% CI [-1.52, -0.93]); in herpangina, shortening the duration of fever (MD -0.68 days, 95% CI [-1.15, -0.21], I2 = 68%, n = 140, 2 trials) and blistering (MD -0.99 days, 95% CI [-1.23, -0.76], n = 386, 3 trials); in acute tonsillitis and acute pharyngitis shortening the duration of fever (MD -1.13 days, 95% CI [-1.36, -0.90], I 2 = 33%, n = 688, 7 trials) and sore throat (MD -1.13 days, 95% CI [-1.40, -0.86], I 2 = 84.1%, n = 1194, 10 trials). SFJD also improving their cure rate with a range (1-5 days). No serious adverse events were reported.

Conclusion: Low certainty evidence suggests that SFJD appears to shorten the duration of symptoms in AURTIs, improve cure rate and seems safe for application. However, high quality placebo controlled trials are warranted to confirm its benefit.

Keywords: Chinese herbal medicine; Randomized controlled trials; Respiratory tract infections; Shufeng Jiedu; Systematic review.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig 1
Fig. 1
Flow chart of study selection. RCT: randomized controlled trials; URTIs: upper respiratory tract infections.
Fig 2
Fig. 2
(a) Risk of bias summary. Fig. 2(b) Risk of bias graph.
Fig 3
Fig. 3
Cure rate with a range (1–5days) of treatment in common cold. SFJD, Shufeng Jiedu.
Fig 4
Fig. 4
Time to fever resolution (d) in acute tonsillitis and acute pharyngitis.SFJD, Shufeng Jiedu.
See this image and copyright information in PMC

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