Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr;8(2):183-188.
doi: 10.1016/j.ajur.2020.03.001. Epub 2020 Mar 7.

Age-specific reference ranges of prostate-specific antigen in the elderly of Amirkola: A population-based study

Hosseini Seyed Reza  1 , Zabihi Ali  1 , Habibian Tara  1 , Bijani Ali  1
Affiliations

Age-specific reference ranges of prostate-specific antigen in the elderly of Amirkola: A population-based study

Hosseini Seyed Reza et al. Asian J Urol. 2021 Apr.

Abstract

Objective: To determine the age-specific reference ranges of prostate-specific antigen (PSA) in the older men in the city of Amirkola.

Methods: This cross-sectional study is a part of Amirkola Health and Ageing Project (AHAP) which has been conducted as a cohort study since 2011 in Amirkola, a city in northern Iran. The demographic information of all men aged 60 and older were collected through questionnaires and interviews and the PSA measurements were performed using ELISA and Diametra kit. The acquired data were analyzed afterwards.

Results: A number of 837 elderly men with a mean age of 69.99±7.72 years participated in this study. The serum PSA level (95th percentile) was determined to be 0.9 (0-4.89) ng/mL in the age group of 60-64 years, 1.1 (0-4.88) ng/mL in the age group of 65-69 years, 0.93 (0-9.01) ng/mL in the age group of 70-74 years, 1.3 (0-7.95) ng/mL in the age group of 75-79 years, 1.9 (0-11.98 ng/mL) in the age group of 80-84 years, and 1.45 (0-33.17) ng/mL in the 85 and older group. The serum PSA level was significantly correlated with age (p=0.000).

Conclusion: This study indicated that there is a direct correlation between the age and serum PSA levels. The use of age-specific reference range could guide clinicians on the incidence of prostate cancer in this population and perhaps reduce the number of unnecessary tests in this population group.

Keywords: Age; Elderly; Population; Prostate-specific antigen; Reference value.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mean serum PSA levels (ng/mL) according to age groups. CI, confidence interval. IPSS, International Prostate Symptoms Scale; PSA, prostate-specific antigen.
Figure 2
Figure 2
Median serum PSA levels (ng/mL) according to age groups. IPSS, International Prostate Symptoms Scale; PSA, prostate-specific antigen.
Figure 3
Figure 3
Serum PSA levels (ng/mL) according to the age and International Prostate Symptoms Scale (IPSS) score; PSA, prostate-specific antigen.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7–30. - PubMed
    1. Zaytsev S., Nikitaev V., Pronichev A., Nagornov O., Polyakov E., Romanov N. A method of data structuring in the decision-making support system in oncological diagnostics of prostate diseases. J Phys Conf Ser. 2017;798:12132.
    1. Ankerst D.P., Pollock B.H., Liang Y., Dizdarevic N., Kyrylenko S., Boeck A. Trends and co-trends of prostate-specific antigen and body mass index in a screened population. Urology. 2011;78:10–16. - PMC - PubMed
    1. Liu M., Wang J., Zhu L., Wan G. Body mass index and serum lipid profile influence serum prostate-specific antigen in Chinese men younger than 50 years of age. Asian J Androl. 2011;13:640. - PMC - PubMed
    1. Rahimifar S., Montazeri A. Age-related prostate specific antigen reference ranges in healthy northern Iranian men. Iran J Immunol. 2018;15:68–73. - PubMed