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. 2021 Apr 28:8:646500.
doi: 10.3389/fvets.2021.646500. eCollection 2021.

Protein Electrophoresis and Haptoglobin Values for Captive Bongo (Tragelaphus eurycerus)

Susan L Bartlett  1 , Nadine Lamberski  2 , Kristopher L Arheart  3 , Carolyn Cray  4
Affiliations

Protein Electrophoresis and Haptoglobin Values for Captive Bongo (Tragelaphus eurycerus)

Susan L Bartlett et al. Front Vet Sci. .

Abstract

Serum samples collected from 37 clinically normal bongo (Tragelaphus eurycerus) and 13 abnormal bongo were tested using assays for acute-phase proteins (APPs) and by protein electrophoresis. Abnormal bongo samples (n = 27) had significantly higher levels of fibrinogen (FIB) (p < 0.001) and trending but not significantly increased haptoglobin (HP) (p = 0.07) vs. samples from normal bongo (n = 37). There were no significant differences in values for total white blood cell counts or for any of the fractions determined by protein electrophoresis. Clinically normal female bongo (n = 19) had significantly lower levels of FIB than normal males (n = 18) (p = 0.014), and this observation was also made with samples from the clinically abnormal group (p = 0.004). Many weak to moderate significant correlations were observed with increasing age, including increased globulins, FIB, and HP and decreased albumin-to-globulin (A/G) ratio and albumin. In clinical cases reviewed in this study, mild HP changes categorized this reactant as a minor APP, which contrasts with the major APP classification of HP in the related species of the cow. The preliminary data indicate that the quantitation of these APPs may offer value in assessing inflammation in this species, but additional studies are needed.

Keywords: acute phase protein; antelope; bongo; bovid; inflammation; reference interval.

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Conflict of interest statement

The authors declare that the research conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Representative normal (A) and abnormal (B) electrophoretograms of the bongo. The fractions, from left to right, are albumin, alpha 1, alpha 2, beta, and gamma globulins. The A/G ratio of the electorphoretograms is 0.69 and 0.36, respectively.
See this image and copyright information in PMC

References

    1. Cray C. Acute phase proteins in animals. Prog Mol Biol Transl Sci. (2012) 105:113–50. 10.1016/B978-0-12-394596-9.00005-6 - DOI - PMC - PubMed
    1. Eckersall PD, Bell R. Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet J. (2010) 185:23–7. 10.1016/j.tvjl.2010.04.009 - DOI - PubMed
    1. Ceron JJ, Eckersall PD, Martynez-Subiela S. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol. (2005) 34:85–99. 10.1111/j.1939-165x.2005.tb00019.x - DOI - PubMed
    1. Petersen HH, Nielsen JP, Heegaard PM. Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res. (2004) 35:163–87. 10.1051/vetres:2004002 - DOI - PubMed
    1. Cray C, Dickey M, Brewer LB, Arheart KL. Assessement of serum amyloid A levels in the rehabilitation setting in the Florida manatee (Trichechus manatus latirostris). J Zoo Wildl Med. (2013) 44:911–7. 10.1638/2012-0270R.1 - DOI - PubMed