Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Apr 27:2021:5557309.
doi: 10.1155/2021/5557309. eCollection 2021.

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Amir Hossein Aalami  1 , Hossein Abdeahad  2 , Mohammad Mesgari  3 , Thozhukat Sathyapalan  4 , Amirhossein Sahebkar  5   6   7
Affiliations
Meta-Analysis

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Amir Hossein Aalami et al. Biomed Res Int. .

Retraction in

Abstract

Aims: Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients' urine with bladder neoplasm.

Methods: We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10th October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR+), negative likelihood ratio (LR-), Q ∗ index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients.

Results: Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66-0.75), specificity of 0.78 (95% CI: 0.73-0.81), LR+ of 3.34 (95% CI: 2.02-5.53), LR- of 0.37 (95% CI: 0.32-0.44), DOR of 9.99 (95% CI: 4.69-21.28), and AUC of 0.789 and Q ∗ index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa.

Conclusion: This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of the study selection.
Figure 2
Figure 2
The sensitivity (a), specificity (b), LR+ (c), LR− (d), and DOR (e) forest plots for the diagnosing role of ANG in the bladder carcinoma patients based on the random effects model.
Figure 3
Figure 3
The ROC plane curve (a) and SROC (b) for diagnosing the role of ANG in the bladder carcinoma patients based on the random effects model.
Figure 4
Figure 4
The diagnostic odds ratio based on the fixed effects model meta-analysis performed with CMA software.
See this image and copyright information in PMC

References

    1. Crispen P. L., Kusmartsev S. Mechanisms of immune evasion in bladder cancer. Cancer Immunology, Immunotherapy. 2020;69:3–14. doi: 10.1007/s00262-019-02443-4. - DOI - PMC - PubMed
    1. Bray F., Ferlay J., Soerjomataram I., Siegel R. L., Torre L. A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a Cancer Journal for Clinicians. 2018;68(6):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Ferlay J., Colombet M., Soerjomataram I., et al. Global Cancer Observatory: Cancer Today. Lyon, France:: International Agency for Research on Cancer; 2018.
    1. Richters A., Aben K. K., Kiemeney L. A. The global burden of urinary bladder cancer: an update. World Journal of Urology. 2020;38(8):1895–1904. doi: 10.1007/s00345-019-02984-4. - DOI - PMC - PubMed
    1. Farmanfarma K. K., Mahdavifar N., Salehiniya H. Bladder cancer in Iran: an epidemiological review. Research and Reports in Urology. 2020;12:91–103. doi: 10.2147/RRU.S232417. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources